Document Detail

Stimulation of anaerobic metabolism in rats at high altitude hypoxia--adrenergic effects dependent on dietary states.
MedLine Citation:
PMID:  2892645     Owner:  NLM     Status:  MEDLINE    
1. Plasma lactate and pyruvate were increased more markedly in fed rats than in fasted rats exposed to an 8000 m altitude. 2. The increase in plasma lactate and pyruvate was enhanced and inhibited by the alpha 1-adrenergic antagonist prazosin and the beta-blocker propranolol, respectively, in fasted rats exposed to an 8000 m altitude. Blood glucose was not changed by adrenergic blockades under the same conditions. 3. Prazosin and propranolol showed no effect on glycolytic metabolites in plasma in fed rats submitted to an 8000 m altitude. Blood glucose of fed rats was increased by alpha 1-blockade during severe hypoxia. 4. In fasted rats whose energy metabolism depends on oxidation mainly, alpha 1- and beta-adrenergic receptors can participate in the stimulation of respiration and the glycogen degradation, respectively, during an exposure to severe hypoxia. In fed rats energy metabolism depends on glycolysis, which utilizes blood glucose as the substrate preferentially during hypoxia.
M Yoshino; K Murakami; Y Katsumata; A Takabayashi; S Mori
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Comparative biochemistry and physiology. B, Comparative biochemistry     Volume:  88     ISSN:  0305-0491     ISO Abbreviation:  Comp. Biochem. Physiol., B     Publication Date:  1987  
Date Detail:
Created Date:  1988-03-02     Completed Date:  1988-03-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2984730R     Medline TA:  Comp Biochem Physiol B     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  651-4     Citation Subset:  IM; S    
Department of Biochemistry, Yokohama City University School of Medicine, Japan.
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MeSH Terms
Adrenergic alpha-Antagonists / pharmacology*
Adrenergic beta-Antagonists / pharmacology*
Altitude Sickness / metabolism*
Anaerobiosis / drug effects
Anoxia / metabolism*
Blood Glucose / metabolism
Lactates / blood
Lactic Acid
Pyruvates / blood
Pyruvic Acid
Rats, Inbred Strains
Reg. No./Substance:
0/Adrenergic alpha-Antagonists; 0/Adrenergic beta-Antagonists; 0/Blood Glucose; 0/Lactates; 0/Pyruvates; 127-17-3/Pyruvic Acid; 50-21-5/Lactic Acid

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