| Stimulation of Na(+)-H+ exchange, the Na(+)-K+ pump and Na+,K+,Cl- cotransport by endothelin-1 in cultured vascular smooth muscle cells. | |
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MedLine Citation:
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PMID: 2561135 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Endothelin-1 concentrations higher than 10(-10) mol/l were able to strongly stimulate Na(+)-H+ exchange, the Na(+)-K+ pump and the Na+,K+Cl- cotransport system in A10 vascular smooth muscle cells. The stimulation of Na(+)-H+ exchange was more marked in fresh than in H(+)-loaded cells, suggesting an increase in the apparent affinity for internal H+. Pump stimulation appeared to be secondary to sodium entry through Na(+)-H+ exchange because it was absent in (1) Na(+)-loaded cells and (2) in the presence of ethyl-isopropylamiloride (EIPA). Stimulation of cotransport was blocked by indomethacin, suggesting the involvement of a cyclo-oxygenase product. In conclusion, the action of endothelin-1 in vascular smooth muscle induces the onset of negative feedback mechanisms which enhance the ability of the vascular cells to regulate disturbances in Na+,K+ and Cl- contents. |
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Authors:
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C Rosati; E Jeanclos; C Nazaret; P E Chabrier; P Hannaert; P Braquet; R Garay |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of hypertension. Supplement : official journal of the International Society of Hypertension Volume: 7 ISSN: 0952-1178 ISO Abbreviation: J Hypertens Suppl Publication Date: 1989 Dec |
Date Detail:
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Created Date: 1990-05-11 Completed Date: 1990-05-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8501422 Medline TA: J Hypertens Suppl Country: ENGLAND |
Other Details:
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Languages: eng Pagination: S138-9 Citation Subset: IM |
Affiliation:
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INSERM U 7/CNRS UA 318, Hôpital Necker, Paris, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biological Transport
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drug effects,
physiology Cell Line / drug effects, metabolism Cells, Cultured / drug effects, metabolism Chlorine / metabolism* Dose-Response Relationship, Drug Endothelins Endothelium, Vascular / physiology* Humans Muscle, Smooth, Vascular / drug effects*, metabolism Peptides / pharmacology* Potassium / metabolism* Potassium Channels / drug effects*, metabolism Sodium / metabolism* Sodium Channels / drug effects*, metabolism Stimulation, Chemical |
| Chemical | |
Reg. No./Substance:
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0/Endothelins; 0/Peptides; 0/Potassium Channels; 0/Sodium Channels; 7440-09-7/Potassium; 7440-23-5/Sodium; 7782-50-5/Chlorine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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