| Stimulation of L-ornithine uptake and L-citrulline and urea biosynthesis by D-arginine. | |
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MedLine Citation:
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PMID: 1930251 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The action of D-arginine on isolated cells and mitochondria obtained from rat liver was studied. The D-amino acid at 200 microM stimulated by 40% the rate of urea biosynthesis by isolated hepatocytes. Citrulline formation was increased 60-70% in rat liver mitochondria incubated with 10 microM D-arginine. In these mitochondria, ornithine uptake was enhanced 204% with 1 microM D-arginine. Inhibition in urea and citrulline synthesis and in ornithine uptake was recorded with high concentrations of the D-amino acid. Respiratory control in liver mitochondria with glutamate-malate was inhibited 32% by 100 microM D-arginine. In isolated mitochondria loaded with Fluo-3-acetoxymethyl (AM) ester, 50 microM D-arginine diminished the matrix free calcium concentration. |
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Authors:
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A Saavedra-Molina; E Piña |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biochemistry international Volume: 24 ISSN: 0158-5231 ISO Abbreviation: Biochem. Int. Publication Date: 1991 May |
Date Detail:
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Created Date: 1991-11-06 Completed Date: 1991-11-06 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8100311 Medline TA: Biochem Int Country: AUSTRALIA |
Other Details:
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Languages: eng Pagination: 349-57 Citation Subset: IM |
Affiliation:
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Departamento de Bioquímica, Facultad de Medicina, U.N.A.M., México, D.F. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphate
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metabolism Animals Arginine / pharmacology* Citrulline / biosynthesis*, metabolism Edetic Acid / pharmacology Liver / cytology, drug effects*, metabolism Male Mitochondria, Liver / drug effects*, metabolism Ornithine / metabolism* Rats Rats, Inbred Strains Spectrometry, Fluorescence Urea / metabolism* |
| Chemical | |
Reg. No./Substance:
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372-75-8/Citrulline; 56-65-5/Adenosine Triphosphate; 57-13-6/Urea; 60-00-4/Edetic Acid; 7006-33-9/Ornithine; 74-79-3/Arginine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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