Document Detail

Stimulation of L-ornithine uptake and L-citrulline and urea biosynthesis by D-arginine.
MedLine Citation:
PMID:  1930251     Owner:  NLM     Status:  MEDLINE    
The action of D-arginine on isolated cells and mitochondria obtained from rat liver was studied. The D-amino acid at 200 microM stimulated by 40% the rate of urea biosynthesis by isolated hepatocytes. Citrulline formation was increased 60-70% in rat liver mitochondria incubated with 10 microM D-arginine. In these mitochondria, ornithine uptake was enhanced 204% with 1 microM D-arginine. Inhibition in urea and citrulline synthesis and in ornithine uptake was recorded with high concentrations of the D-amino acid. Respiratory control in liver mitochondria with glutamate-malate was inhibited 32% by 100 microM D-arginine. In isolated mitochondria loaded with Fluo-3-acetoxymethyl (AM) ester, 50 microM D-arginine diminished the matrix free calcium concentration.
A Saavedra-Molina; E Piña
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochemistry international     Volume:  24     ISSN:  0158-5231     ISO Abbreviation:  Biochem. Int.     Publication Date:  1991 May 
Date Detail:
Created Date:  1991-11-06     Completed Date:  1991-11-06     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8100311     Medline TA:  Biochem Int     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  349-57     Citation Subset:  IM    
Departamento de Bioquímica, Facultad de Medicina, U.N.A.M., México, D.F.
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MeSH Terms
Adenosine Triphosphate / metabolism
Arginine / pharmacology*
Citrulline / biosynthesis*,  metabolism
Edetic Acid / pharmacology
Liver / cytology,  drug effects*,  metabolism
Mitochondria, Liver / drug effects*,  metabolism
Ornithine / metabolism*
Rats, Inbred Strains
Spectrometry, Fluorescence
Urea / metabolism*
Reg. No./Substance:
372-75-8/Citrulline; 56-65-5/Adenosine Triphosphate; 57-13-6/Urea; 60-00-4/Edetic Acid; 7006-33-9/Ornithine; 74-79-3/Arginine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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