Document Detail


Stimulation of Kaposi's sarcoma cell growth by urine from women in early pregnancy, the current source for clinical-grade human chorionic gonadotropin preparations.
MedLine Citation:
PMID:  12190946     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Clinical-grade preparations of human chorionic gonadotropin (hCG) have been shown to be toxic to Kaposi's sarcoma (KS) cells. However, the results of clinical studies using commercial hCG preparations KS remain highly contradictory. More particularly, some hCG preparations could have a paradoxical growth effect on KS. Such discrepant results may be explained by the fact that the anti-KS activity is not associated with hCG itself but with one or more factors that are co-purified with the hormone. We found here that crude urine from first trimester pregnant women, the current source for commercial hCG, had a growth stimulatory effect on KS cells. By contrast, urine from last trimester pregnant women, from non-pregnant young women, from menopausal women and from men exhibited neither a growth stimulatory nor a growth inhibitory effect on KS cells. The amplitude of this pregnancy urine-associated pro-KS activity/hCG unit was higher than that achieved with clinical-grade hCG preparations. Partial co-purification of pregnancy-associated factors during the extraction procedure of commercial hCG from urine may explain the pro-KS activity achieved with some hCG preparations. We, therefore, suggest a cautious use of hCG purified from pregnancy urine for the treatment of KS.
Authors:
T Simonart; P Hermans; J Delogne-Desnoeck; J P Van Vooren; S Meuris
Related Documents :
15969756 - A link between high serum levels of human chorionic gonadotrophin and chorionic express...
16225426 - Purification of human chorionic gonadotropin from pregnancy urine by immunoaffinity chr...
73406 - Tumour antigens associated with primary mediastinal choriocarcinoma.
19182846 - Ruptured tubal ectopic pregnancy with negative serum beta hcg--a case for ongoing vigil...
10369206 - Immature oocyte retrieval with in-vitro oocyte maturation.
25180106 - A foreign body in the cervix after spontaneous abortion: a rare case of a traumatic fet...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Experimental dermatology     Volume:  11     ISSN:  0906-6705     ISO Abbreviation:  Exp. Dermatol.     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-08-22     Completed Date:  2003-03-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9301549     Medline TA:  Exp Dermatol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  365-9     Citation Subset:  IM    
Affiliation:
Department of Dermatology, Erasme University Hospital, B-1070 Brussels, Belgium. tsimonar@ulb.ac.be
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Cell Division / drug effects
Chorionic Gonadotropin / isolation & purification,  pharmacology*,  therapeutic use,  urine
Endothelium, Vascular / cytology,  drug effects
Female
Humans
Male
Pregnancy
Pregnancy Complications, Neoplastic / pathology
Sarcoma, Kaposi / complications,  drug therapy*,  pathology
Skin / blood supply
Tumor Cells, Cultured
Chemical
Reg. No./Substance:
0/Chorionic Gonadotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Epidermal CD8+ T cells reactive with group A streptococcal antigens in chronic plaque psoriasis.
Next Document:  The effect of topically applied salicylic compounds on serotonin-induced scratching behaviour in hai...