| Stimulation of IGF-binding protein-1 secretion by AMP-activated protein kinase. | |
| | |
MedLine Citation:
|
PMID: 11302732 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Insulin-like growth factor-binding protein-1 (IGFBP-1) is stimulated during intensive exercise and in catabolic conditions to very high concentrations, which are not completely explained by known regulators such as insulin and glucocorticoids. The role of AMP-activated protein kinase (AMPK), an important signaling system in lipid and carbohydrate metabolism, in regulating IGFBP-1 was studied in H4-II-E rat hepatoma cells. Arsenic(III) oxide and 5-aminoimidazole-4-carboxamide-riboside (AICAR) were used as activators. AICAR (150 microM) stimulated IGFBP-1 secretion twofold during a 5-h incubation (P = 0.002). Insulin (100 ng/ml) inhibited IGFBP-1 by 80% (P < 0.001), but this was completely abolished in the presence of 150 microM AICAR. The effect of dexamethasone in stimulating IGFBP-1 threefold was additive to the effect of AICAR (P < 0.001) and, in the presence of AICAR, was incompletely inhibited by insulin. In conclusion AMPK is identified as a novel regulatory pathway for IGFBP-1, stimulating secretion and blocking the inhibitory effect of insulin. |
| | |
Authors:
|
M S Lewitt |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Biochemical and biophysical research communications Volume: 282 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 2001 Apr |
Date Detail:
|
Created Date: 2001-04-16 Completed Date: 2001-05-17 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: United States |
Other Details:
|
Languages: eng Pagination: 1126-31 Citation Subset: IM |
Copyright Information:
|
Copyright 2001 Academic Press. |
Affiliation:
|
Department of Molecular Medicine, Karolinska Institutet, Stockholm, S-171 76, Sweden. moira@enk.ks.se |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
AMP-Activated Protein Kinases Aminoimidazole Carboxamide / analogs & derivatives*, pharmacology Animals Arsenicals / pharmacology Carcinoma, Hepatocellular / metabolism* Culture Media, Conditioned / chemistry Dexamethasone / antagonists & inhibitors, pharmacology Dose-Response Relationship, Drug Drug Antagonism Glucocorticoids / antagonists & inhibitors, pharmacology Insulin / pharmacology Insulin Antagonists / pharmacology Insulin-Like Growth Factor Binding Protein 1 / analysis, metabolism, secretion* Multienzyme Complexes / metabolism* Oxides / pharmacology Protein-Serine-Threonine Kinases / metabolism* Rats Ribonucleotides / pharmacology Signal Transduction / drug effects Tumor Cells, Cultured |
| Chemical | |
Reg. No./Substance:
|
0/Arsenicals; 0/Culture Media, Conditioned; 0/Glucocorticoids; 0/Insulin Antagonists; 0/Insulin-Like Growth Factor Binding Protein 1; 0/Multienzyme Complexes; 0/Oxides; 0/Ribonucleotides; 11061-68-0/Insulin; 1327-53-3/arsenic trioxide; 3031-94-5/AICA ribonucleotide; 360-97-4/Aminoimidazole Carboxamide; 50-02-2/Dexamethasone; EC 2.7.11.1/AMP-Activated Protein Kinases; EC 2.7.11.1/Protein-Serine-Threonine Kinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cadmium induces phosphorylation of p53 at serine 15 in MCF-7 cells.
Next Document: xCt cystine transporter expression in HEK293 cells: pharmacology and localization.