Document Detail


Stimulation of DNA synthesis but not of peroxisomal beta-oxidation by nafenopin in primary cultures of marmoset hepatocytes.
MedLine Citation:
PMID:  3147145     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of the peroxisome proliferator nafenopin upon primary cultures of marmoset hepatocytes have been investigated and compared to those on cultured rat hepatocytes. Nafenopin did not induce peroxisomal beta-oxidation or peroxisome proliferation but did induce replicative DNA synthesis. These findings demonstrate that peroxisome proliferation and mitogenicity are two independent properties of nafenopin and question the widely held view that primates are generally insensitive to the effects of peroxisome proliferators.
Authors:
F Bieri; W Stäubli; F Waechter; S Muakkassah-Kelly; P Bentley
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cell biology international reports     Volume:  12     ISSN:  0309-1651     ISO Abbreviation:  Cell Biol. Int. Rep.     Publication Date:  1988 Dec 
Date Detail:
Created Date:  1989-03-27     Completed Date:  1989-03-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7708050     Medline TA:  Cell Biol Int Rep     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1077-87     Citation Subset:  IM    
Affiliation:
Central Toxicology Unit, Ciba-Geigy Limited, Basel, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Animals
Callitrichinae / metabolism*
Cells, Cultured
DNA / biosynthesis*
Liver / cytology*,  drug effects,  metabolism
Male
Microbodies / drug effects,  metabolism*
Nafenopin / pharmacology*,  toxicity
Oxidation-Reduction / drug effects
Propionates / pharmacology*
Chemical
Reg. No./Substance:
0/Propionates; 3771-19-5/Nafenopin; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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