Document Detail

Stimulation of B lymphocytes by lipopolysaccharides from anaerobic bacteria.
MedLine Citation:
PMID:  8324119     Owner:  NLM     Status:  MEDLINE    
Lipopolysaccharides (LPSs) from anaerobic gram-negative bacteria, including those of low endotoxic activity that are isolated from Bacteroides, Prevotella, and Porphyromonas are potent inducers of DNA replication and polyclonal immunoglobulin production in murine B lymphocytes. The activation is dose-dependent and T cell-independent. Replication of DNA and production of immunoglobulins were also stimulated by lipid A and by the LPS heteropolysaccharide that were isolated by mild acid hydrolysis of the LPSs of Bacteroides fragilis and Fusobacterium nucleatum. Combinations of LPS, lipid A, and acid-degraded polysaccharide amplified the blastogenic response. Antibodies that react with the polysaccharide part of LPSs isolated from members of the Bacteroidaceae are present in healthy human serum.
T Hofstad; N Skaug; K Sveen
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Publication Detail:
Type:  In Vitro; Journal Article; Review    
Journal Detail:
Title:  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America     Volume:  16 Suppl 4     ISSN:  1058-4838     ISO Abbreviation:  Clin. Infect. Dis.     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-08-12     Completed Date:  1993-08-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9203213     Medline TA:  Clin Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S200-2     Citation Subset:  IM    
Department of Microbiology and Immunology, Gade Institute, University of Bergen, Norway.
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MeSH Terms
B-Lymphocytes / drug effects*,  immunology
Bacteria, Anaerobic
Carbohydrate Sequence
Lipid A / chemistry
Lipopolysaccharides / isolation & purification,  pharmacology*
Lymphocyte Activation / drug effects
Molecular Sequence Data
Molecular Structure
Reg. No./Substance:
0/Lipid A; 0/Lipopolysaccharides

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