| Stimulating effect of thyroid hormone on insulin-like growth factor I release and synthesis by perfused rat liver. | |
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MedLine Citation:
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PMID: 1842559 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The direct effect of thyroid hormone on insulin-like growth factor I (IGF-I) release and synthesis was investigated in perfused rat liver. Physiological doses (from 50 to 1000 ng/dl) of 3,5,3'-triiodothyronine administration in the perfusing medium increased IGF-I release and concentration in the perfused liver in a dose dependent manner. While physiological doses (from 2 to 10 micrograms/dl) of thyroxine did not affect the release and synthesis of IGF-I in the perfused liver. These results suggest that 3,5,3'-triiodothyronine, but not thyroxine, directly enhances the release and synthesis of IGF-I in a dose dependent manner in the rat liver. |
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Authors:
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T Ikeda; K Fujiyama; T Hoshino; Y Tanaka; T Takeuchi; H Mashiba; M Tominaga |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Growth regulation Volume: 1 ISSN: 0956-523X ISO Abbreviation: Growth Regul. Publication Date: 1991 Mar |
Date Detail:
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Created Date: 1993-01-13 Completed Date: 1993-01-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9106990 Medline TA: Growth Regul Country: SCOTLAND |
Other Details:
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Languages: eng Pagination: 39-41 Citation Subset: IM |
Affiliation:
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First Department of Internal Medicine, Tottori University School of Medicine, Yonago, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dose-Response Relationship, Drug Insulin-Like Growth Factor I / biosynthesis, secretion* Liver / drug effects*, secretion Male Oxygen Consumption / drug effects Perfusion Rats Rats, Wistar Thyroxine / pharmacology Triiodothyronine / pharmacology* |
| Chemical | |
Reg. No./Substance:
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67763-96-6/Insulin-Like Growth Factor I; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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