Document Detail

Stimulating consciousness and cognition following severe brain injury: a new potential clinical use for lamotrigine.
MedLine Citation:
PMID:  11104139     Owner:  NLM     Status:  MEDLINE    
No medications clearly enhance consciousness or cognition following severe brain injury. This series (n = 13) suggests that lamotrigine may stimulate improvement of patients with impairment equivalent to level I-III on the Rancho Los Amigos Cognitive Scale. After a serendiptious clinical result, severely brain injured patients who were taking an anticonvulsant had an opportunity to start lamotrigine. This cohort had been transferred to this rehabilitation unit 14-304 (mean 73.9) days and started lamotrigine 20-310 (mean 87.5) days after acute brain injury. Compared to this unit's experience with patients with similar severe brain injuries, more patients (n = 10) were discharged to the conmmunity and fewer to skilled nursing facilities (n = 3) than were expected. This preliminary and provocative case series corresponds to basic science results, and further investigation of lamotrigine is warranted.
P E Showalter; D N Kimmel
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain injury     Volume:  14     ISSN:  0269-9052     ISO Abbreviation:  Brain Inj     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2001-03-06     Completed Date:  2001-05-31     Revised Date:  2014-11-14    
Medline Journal Info:
Nlm Unique ID:  8710358     Medline TA:  Brain Inj     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  997-1001     Citation Subset:  IM    
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MeSH Terms
Activities of Daily Living
Anticonvulsants / administration & dosage,  therapeutic use
Brain Injuries / complications,  drug therapy*,  psychology,  rehabilitation*
Cognition / drug effects*
Excitatory Amino Acid Antagonists / administration & dosage,  therapeutic use*
Middle Aged
Patient Discharge / statistics & numerical data
Psychiatric Status Rating Scales
Recovery of Function
Seizures / etiology,  prevention & control*
Trauma Severity Indices
Triazines / administration & dosage,  therapeutic use*
Reg. No./Substance:
0/Anticonvulsants; 0/Excitatory Amino Acid Antagonists; 0/Triazines; U3H27498KS/lamotrigine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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