| Stimulated pancreatic exocrine secretion does not require pancreatic hyperemia in rats. Potential cholinergic role. | |
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MedLine Citation:
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PMID: 8100758 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although blood flow and cholinergic tone influence gastric and salivary gland secretion, their role in pancreatic secretion is poorly defined. The purpose of the present study was: (1) to test the hypothesis that an increase in pancreatic blood flow accompanies stimulated pancreatic exocrine secretion, and (2) to examine the effects of cholinergic agents on basal and stimulated blood flow using hydrogen gas clearance. Stimulated pancreatic exocrine secretion (secretin 0.4, 0.8, 1.6 micrograms/kg/hr) resulted in a significant (P < 0.005) increase in secretory volume; however, pancreatic blood flow was not significantly changed, and a negative correlation between blood flow and secretion was observed. A pharmacologic dose of secretin (5.0 micrograms/kg/hr) resulted in a significant (P < 0.05) increase in pancreatic blood flow, which was inhibited by atropine (5.0 micrograms/kg/hr) infusion. Although 2-deoxyglucose caused a significant decrease (P < 0.03) in basal pancreatic blood flow, atropine had no effect on basal blood flow levels. These observations suggest that: (1) under physiologic conditions, secretin- or 2-deoxyglucose-stimulated pancreatic secretion does not require pancreatic hyperemia; (2) a pharmacologic dose of secretin does produce pancreatic hyperemia, perhaps through a local cholinergic mechanism; (3) peripheral cholinergic tone does not contribute significantly to basal pancreatic blood flow; and (4) basal pancreatic blood flow may be influenced by central mechanisms. |
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Authors:
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R L Conter; J L Washington; G L Kauffman |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Digestive diseases and sciences Volume: 38 ISSN: 0163-2116 ISO Abbreviation: Dig. Dis. Sci. Publication Date: 1993 Jul |
Date Detail:
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Created Date: 1993-08-12 Completed Date: 1993-08-12 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7902782 Medline TA: Dig Dis Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1270-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Surgery, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Atropine / administration & dosage Deoxyglucose / pharmacology Dose-Response Relationship, Drug Hydrogen / diagnostic use Hyperemia / chemically induced, epidemiology, physiopathology* Isoproterenol / pharmacology Male Pancreas / blood supply*, drug effects, secretion* Rats Rats, Sprague-Dawley Receptors, Cholinergic / drug effects, physiology* Regional Blood Flow / drug effects Regression Analysis Secretin / administration & dosage Somatostatin / pharmacology Stimulation, Chemical Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Cholinergic; 1333-74-0/Hydrogen; 1393-25-5/Secretin; 154-17-6/Deoxyglucose; 51-55-8/Atropine; 51110-01-1/Somatostatin; 7683-59-2/Isoproterenol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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