Document Detail

Stimulated dopamine overflow and alpha-synuclein expression in the nucleus accumbens core distinguish rats bred for differential ethanol preference.
MedLine Citation:
PMID:  20533994     Owner:  NLM     Status:  MEDLINE    
The key neurochemical systems and structures involved in the predisposition to substance abuse and preference to ethanol (EtOH) are not known in detail but clearly dopamine (DA) is an important modulator of addiction. Recent data indicate that alpha-synuclein (alpha-syn), a pre-synaptic protein, plays a role in regulation of DA release from the pre-synaptic terminals in striatum and the expression of this protein is different after drug abuse or following abstinence. In the present work, we analysed stimulated DA overflow in the dorsal and ventral striatum in EtOH naïve alko alchohol (AA) and alko non-alchohol (ANA) rats selected for more than 100 generations for their differential EtOH preference. In the same structures, we studied the expression of alpha-syn using western blotting. AA rats, in comparison with ANA rats, showed a marked reduction of stimulated peak DA overflow and higher levels of alpha-syn in the nucleus accumbens core. In the same structure, DA re-uptake was increased in AA rats in comparison with ANA rats. The effects of EtOH at low (0.1 g/kg) and higher (3 mg/kg) doses on DA overflow measured in the nucleus accumbens shell were similar in both lines. These results indicate that high expression of alpha-syn may contribute to the reduced DA overflow and the possible activation of re-uptake in the nucleus accumbens core of AA rats in comparison with ANA rats.
Anssi Pelkonen; Mikko Hiltunen; Kalervo Kiianmaa; Leonid Yavich
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-06-01
Journal Detail:
Title:  Journal of neurochemistry     Volume:  114     ISSN:  1471-4159     ISO Abbreviation:  J. Neurochem.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-26     Completed Date:  2010-10-06     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  2985190R     Medline TA:  J Neurochem     Country:  England    
Other Details:
Languages:  eng     Pagination:  1168-76     Citation Subset:  IM    
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MeSH Terms
Alcohol-Induced Disorders, Nervous System / genetics,  metabolism*
Central Nervous System Depressants / pharmacology
Dopamine / biosynthesis,  metabolism,  physiology*
Dose-Response Relationship, Drug
Ethanol / pharmacology*
Genetic Predisposition to Disease / genetics
Nucleus Accumbens / drug effects*,  metabolism*
Presynaptic Terminals / drug effects,  metabolism
Rats, Inbred Strains
Species Specificity
Synaptic Transmission / drug effects,  physiology
alpha-Synuclein / biosynthesis*,  genetics
Reg. No./Substance:
0/Central Nervous System Depressants; 0/alpha-Synuclein; 3K9958V90M/Ethanol; VTD58H1Z2X/Dopamine

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