Document Detail

Stimulated changes in localized cerebral energy consumption under anesthesia.
MedLine Citation:
PMID:  10077669     Owner:  NLM     Status:  MEDLINE    
Focal changes in the cerebral metabolic rate of glucose utilization (CMRglc) are small (10-40%) during sensory activation in awake humans, as well as in awake rodents and primates (20-50%). They are significantly larger (50-250%) in sensory activation studies of anesthetized rats and cats. Our data, in agreement with literature values, show that in the resting anesthetized state values of CMRglc are lower than in the resting nonanesthetized state whereas the final state values, reached upon activation, are similar for the anesthetized and nonanesthetized animals. The lower resting anesthetized state values of CMRglc explain why the increments upon activation from anesthesia are larger than when starting from the nonanesthetized conditions. Recent 13C NMR measurements in our laboratory have established a quantitative relationship between the energetics of glucose oxidation, CMRglc (oxidative), and the flux of the glutamate/gamma-aminobutyric acid/glutamine neurotransmitter cycle, Vcycle. In both the resting awake value of CMRglc(oxidative), and its increment upon stimulation, a large majority (approximately 80%) of the brain energy consumption is devoted to Vcycle. In the differencing methods of functional imaging, it is assumed that the incremental change in the measured signal represents the modular activity that supports the functional response. However, the same amount of activity must be present during the response to stimulation, irrespective of the initial basal state of the cortex. Thus, whereas the incremental signals of DeltaCMRglc can localize neurotransmitter activity, the magnitude of such activity during the response is represented by the total localized CMRglc, not the increment.
R G Shulman; D L Rothman; F Hyder
Related Documents :
15603919 - Distribution of ytterbium-169 in rat brain after intravenous injection.
19542189 - Feeding signals to the hungry mind.
10025719 - Increased glyceraldehyde 3-phosphate dehydrogenase levels in the brain of patients with...
22161499 - Consensus paper: roles of the cerebellum in motor control-the diversity of ideas on cer...
11431129 - Monitoring nad(p)h autofluorescence to assess mitochondrial metabolic functions in rat ...
6602819 - Regional cerebral metabolic alterations in dementia of the alzheimer type: positron emi...
3558879 - Architecture and frontal cortical connections of the premotor cortex (area 6) in the rh...
6894649 - The af64a-treated mouse: possible model for central cholinergic hypofunction.
3805349 - Ascending pathways from the spinal cord in the himé salmon (landlocked red salmon, onco...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  96     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1999 Mar 
Date Detail:
Created Date:  1999-05-20     Completed Date:  1999-05-20     Revised Date:  2013-04-16    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3245-50     Citation Subset:  IM    
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06510, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Brain / physiology*
Energy Metabolism*
Glucose / physiology*
Grant Support
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Calcium/calmodulin-dependent protein kinase II is associated with the N-methyl-D-aspartate receptor.
Next Document:  The role of immunophilins in mutant superoxide dismutase-1linked familial amyotrophic lateral sclero...