Document Detail

Stimulated DNA synthesis in frog nuclei by cytoplasmic extracts of temperature-sensitive mammalian cells.
MedLine Citation:
PMID:  675253     Owner:  NLM     Status:  MEDLINE    
Cytoplasmic extracts of proliferating cells stimulate DNA synthesis in isolated nuclei of Xenopus laevis liver. When tested by the same assay, cytoplasmic extracts of resting cells are completely inactive. When cytoplasmic extracts are prepared from cell cycle-specific temperature-sensitive mutants arrestd in the G1 phase of the cell cycle by the nonpermissive temperature, they also fail to stimulate DNA synthesis in frog nuclei. The results indicate that, to stimulate DNA synthesis in isolated frog nuclei, essentially all information of G1 cells must be present.
J Floros; H Chang; R Baserga
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  201     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1978 Aug 
Date Detail:
Created Date:  1978-09-25     Completed Date:  1978-09-25     Revised Date:  2007-03-19    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  651-2     Citation Subset:  IM    
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MeSH Terms
Cell Cycle*
Cell Line
Cell Nucleus / metabolism*
Cytoplasm / physiology
DNA / biosynthesis*
Liver / ultrastructure
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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