Document Detail


Stimulated DNA synthesis in frog nuclei by cytoplasmic extracts of temperature-sensitive mammalian cells.
MedLine Citation:
PMID:  675253     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cytoplasmic extracts of proliferating cells stimulate DNA synthesis in isolated nuclei of Xenopus laevis liver. When tested by the same assay, cytoplasmic extracts of resting cells are completely inactive. When cytoplasmic extracts are prepared from cell cycle-specific temperature-sensitive mutants arrestd in the G1 phase of the cell cycle by the nonpermissive temperature, they also fail to stimulate DNA synthesis in frog nuclei. The results indicate that, to stimulate DNA synthesis in isolated frog nuclei, essentially all information of G1 cells must be present.
Authors:
J Floros; H Chang; R Baserga
Related Documents :
6297253 - Growth kinetics of bp8 mouse ascites sarcoma after single doses of whole body irradiati...
10851073 - Cell cycle regulation of the endogenous wild type bloom's syndrome dna helicase.
17201133 - Gefitinib-related gene signature in bladder cancer cells identified by a cdna microarray.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  201     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1978 Aug 
Date Detail:
Created Date:  1978-09-25     Completed Date:  1978-09-25     Revised Date:  2007-03-19    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  651-2     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Cell Cycle*
Cell Line
Cell Nucleus / metabolism*
Chickens
Cytoplasm / physiology
DNA / biosynthesis*
Liver / ultrastructure
Mutation
Temperature
Xenopus
Chemical
Reg. No./Substance:
9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Symbolic communication between two chimpanzees (Pan troglodytes).
Next Document:  Analysis of melatonin in human plasma by gas chromatography negative chemical ionization mass spectr...