Document Detail

Stillbirths and intrauterine infection, histologic chorioamnionitis and microbiological findings.
MedLine Citation:
PMID:  9236308     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To analyze whether placental inflammation is associated with stillbirth in Zimbabwe. METHOD: Placentas from 66 stillbirths (> 22 weeks' gestation; patients with congenital malformations, diabetes or preeclampsia were excluded) and 66 term live births were studied for the presence and severity of chorioamnionitis. The morphological results were compared with earlier presented microbiological findings in the same material. RESULTS: Chorioamnionitis was present in 79% of stillbirths and 30% of live births (O.R. 8.5, 95% C.I. 4.0-18). Nine percent of stillbirths but no live births presented vasculitis of the chorionic plate, which verified an inflammatory response from the infant (O.R. 14, 95% C.I. 2.8-72). The same types of microorganisms were isolated from stillbirths and liveborns, but Escherichia coli and group B streptococci were more frequent among stillbirths. CONCLUSIONS: Morphological chorioamnionitis occurred 2.6 times more often in women with stillbirths than in women with live births. In 9% of stillbirths the infant showed an inflammatory response. Thus the infant was alive when the infection occurred and it is therefore reasonable to assume that infection was the cause of death.
S R Moyo; I Hägerstrand; L Nyström; S A Tswana; J Blomberg; S Bergström; A Ljungh
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics     Volume:  54     ISSN:  0020-7292     ISO Abbreviation:  Int J Gynaecol Obstet     Publication Date:  1996 Aug 
Date Detail:
Created Date:  1997-09-04     Completed Date:  1997-09-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0210174     Medline TA:  Int J Gynaecol Obstet     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  115-23     Citation Subset:  IM    
Department of Medical Microbiology, University of Zimbabwe Medical School, Harare, Zimbabwe.
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MeSH Terms
Cause of Death*
Chorioamnionitis / epidemiology*,  microbiology,  pathology
Developing Countries*
Fetal Death / epidemiology*,  etiology
Placenta / microbiology*,  pathology
Pregnancy Complications, Infectious / epidemiology*,  microbiology,  pathology
Risk Factors
Zimbabwe / epidemiology

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