Document Detail

Stillbirth and infant mortality in singletons by cause of death, birthweight, gestational age and birthweight-for-gestation, Newcastle upon Tyne 1961-2000.
MedLine Citation:
PMID:  20618722     Owner:  NLM     Status:  MEDLINE    
The dramatic reduction observed in stillbirth and infant mortality over the last few decades has not been assessed by both birthweight and gestation. We have explored temporal changes in stillbirth and infant mortality in Newcastle upon Tyne, UK, by cause of death, birthweight, gestational age, birthweight standardised for gestation and infant sex during 1961-2000. We included 131 044 singleton births to mothers resident in Newcastle, including 1342 stillbirths and 1620 infant deaths. Cause-, birthweight-, gestational age- and birthweight-for-gestation-specific stillbirth (per 1000 total births) and infant mortality (per 1000 livebirths) rates were compared between 1961-80 and 1981-2000 and between individual consecutive decades. Between 1961 and 2000, total stillbirth and infant mortality rates declined dramatically from 23.4 to 4.7 per 1000 total births and from 25.7 to 5.9 per 1000 livebirths, respectively. Rates fell continuously during the first two study decades; however, from 1981-90 to 1991-2000 the decline was not statistically significant. Between 1961-80 and 1981-2000, both stillbirth and infant mortality significantly declined in all birthweight and gestational age categories and for most leading causes of death. Although the population mean birthweight during 1981-2000 [3304 g (SD +/- 569)] was significantly higher than during 1961-80 [3255 g (SD +/- 572)] (P < 0.0001), the lowest stillbirth and infant mortality rates in 1981-2000 were consistently at about 1 SD above the mean birthweight, with mortality rates increasing for babies with lower or higher weight-for-gestation. Declines in stillbirth and infant mortality in Newcastle were associated with reductions in birthweight- and gestational age-specific mortality rates and occurred in most cause-specific groups of death.
Svetlana V Glinianaia; Judith Rankin; Mark S Pearce; Louise Parker; Tanja Pless-Mulloli
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Paediatric and perinatal epidemiology     Volume:  24     ISSN:  1365-3016     ISO Abbreviation:  Paediatr Perinat Epidemiol     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-12     Completed Date:  2010-12-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8709766     Medline TA:  Paediatr Perinat Epidemiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  331-42     Citation Subset:  IM    
Institute of Health and Society, The Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
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MeSH Terms
Birth Weight*
Cause of Death
England / epidemiology
Gestational Age*
Infant Mortality / trends*
Infant, Newborn
Stillbirth / epidemiology*
Grant Support
072465/Z/03/Z//Wellcome Trust; //Department of Health

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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