Document Detail

Still a role for plasma exchange in rapidly progressive glomerulonephritis?
MedLine Citation:
PMID:  9241619     Owner:  NLM     Status:  MEDLINE    
Plasmapheresis combined with immunosuppression dramatically improved the survival of patients with Goodpasture's disease in the late 1970's. The presence of circulating pathogenic autoantibodies in this disease provided a logical rationale for the use of plasma exchange therapy. Careful analysis of the response to treatment has suggested that patients presenting with a serum creatinine < 600 mumol/I have the most benefit from plasma exchange. Subsequently plasmapheresis has been tried in a variety of other nephritides, predominantly those causing rapidly progressive glomerulonephritis, with variable success. Initial studies failed adequately to distinguish patients with a number of quite distinct causes of crescentic nephritis. However it has become clear that plasma exchange significantly improves the outcome of patients with pauci-immune crescentic glomerulonephritis who present with severe renal failure requiring dialysis, but not those with less severe renal disease.
J B Levy; C D Pusey
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of nephrology     Volume:  10     ISSN:  1121-8428     ISO Abbreviation:  J. Nephrol.     Publication Date:    1997 Jan-Feb
Date Detail:
Created Date:  1997-09-11     Completed Date:  1997-09-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9012268     Medline TA:  J Nephrol     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  7-13     Citation Subset:  IM    
Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
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MeSH Terms
Anti-Glomerular Basement Membrane Disease / therapy
Disease Progression
Glomerulonephritis / physiopathology*,  therapy*
Plasma Exchange* / adverse effects
Time Factors
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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