| Stilbene-based anticancer agents: resveratrol analogues active toward HL60 leukemic cells with a non-specific phase mechanism. | |
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MedLine Citation:
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PMID: 16580204 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Several stilbenes, related to known resveratrol, have been synthesized and tested for their anticancer effect on HL60 leukemia cell line, taking particular care of the cell cycle analysis. The most potent compound was the known (Z)-3,4',5-trimethoxystilbene (6b) which was active as apoptotic agent at 0.24 microM. Differently from other stilbenes (including resveratrol) that induced a prevalent recruitment of cells in S phase of cell cycle, we found a peculiar behavior of 6b that caused a decrease of cells in all phases of cell cycle (G0-G1, S, and G2-M) and a proportional increase of apoptotic cells. The potent pro-apoptotic activity shown by compound 6b and its effects on cell cycle make this compound of great interest for further investigations. |
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Authors:
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Daniele Simoni; Marinella Roberti; Francesco Paolo Invidiata; Enrico Aiello; Stefania Aiello; Paolo Marchetti; Riccardo Baruchello; Marco Eleopra; Antonietta Di Cristina; Stefania Grimaudo; Nicola Gebbia; Lucia Crosta; Francesco Dieli; Manlio Tolomeo |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-03-31 |
Journal Detail:
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Title: Bioorganic & medicinal chemistry letters Volume: 16 ISSN: 0960-894X ISO Abbreviation: Bioorg. Med. Chem. Lett. Publication Date: 2006 Jun |
Date Detail:
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Created Date: 2006-05-08 Completed Date: 2006-08-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: England |
Other Details:
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Languages: eng Pagination: 3245-8 Citation Subset: IM |
Affiliation:
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Dipartimento di Scienze Farmaceutiche, Via Fossato di Mortara 17-19, Università di Ferrara, 44100 Ferrara, Italy. smd@unife.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antimony
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chemistry* Antineoplastic Agents / chemical synthesis*, chemistry, pharmacology* Cell Proliferation / drug effects HL-60 Cells Humans Molecular Structure Stilbenes / chemical synthesis, chemistry*, pharmacology* Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Stilbenes; 501-36-0/resveratrol; 7440-36-0/Antimony; 7803-52-3/stibine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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