Document Detail


Stiffness of the rib cage in a subset of rheumatoid patients.
MedLine Citation:
PMID:  3132576     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In a previous investigation of lung function in patients with rheumatoid arthritis (RA), we observed that some patients had significant dysfunction of their chest wall mechanics without pleural disease that could contribute to their respiratory symptoms. To investigate further the chest wall functions of patients with RA, we selected 10 female lifetime nonsmoking patients with RA and compared them to 10 paid normal volunteers in detailed functional evaluations of lung and chest wall. Patients with significant airflow limitation were excluded from this study. We found a significant 7% reduction in total lung capacity in the RA patients without significant change in lung compliance. However, we found a significant reduction in rib cage compliance in patients with RA (0.044 +/- 0.006 L/cmH2O vs. 0.064 +/- 0.012 in controls), which was associated with a significant 38% reduction in expansion of the rib cage volume during various breathing maneuvers. These changes occurred in the absence of lung or pleural disease. This study documents that patients with RA have limited expansion of rib cage relative to abdomen, thus rib cage restriction and stiffness, which may contribute to reduced lung volume. The shift of thoracoabdominal breathing configuration observed in patients with RA will likely reduce the effectiveness of breathing muscles and thus could contribute to the dyspnea sensation experienced by patients with RA.
Authors:
R Bégin; V Radoux; A Cantin; H A Ménard
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lung     Volume:  166     ISSN:  0341-2040     ISO Abbreviation:  Lung     Publication Date:  1988  
Date Detail:
Created Date:  1988-07-25     Completed Date:  1988-07-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7701875     Medline TA:  Lung     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  141-8     Citation Subset:  IM    
Affiliation:
Department of Medicine, Université de Sherbrooke, Québec, Canada.
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MeSH Terms
Descriptor/Qualifier:
Arthritis, Rheumatoid / complications*,  physiopathology
Dyspnea / etiology*,  physiopathology
Female
Humans
Middle Aged
Respiratory Function Tests
Respiratory Muscles / physiopathology
Ribs / physiopathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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