Document Detail


Stiffness of the abdominal aorta in beta-thalassemia major patients related with body iron load.
MedLine Citation:
PMID:  17023824     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Increased iron stores have been implicated in the association with increased risk of cardiovascular events. We evaluated whether the abdominal aortic stiffness was altered in the patients with beta-thalassemia major in relation with body iron load.
METHODS: Sixty-two (32 males and 30 females) beta-thalassemia major patients aged 16.47 +/- 4.8 years were enrolled into the study. Healthy 52 subjects matched for age and sex were recruited as controls. In all subjects, hemoglobin, fasting glucose, cholesterol, high-density lipoprotein-cholesterol, and low-density lipoprotein-cholesterol levels were measured. The average serum ferritin level and liver iron concentration (LIC) were assessed in thalassemia patients. Left ventricular function and mass were evaluated echocardiographically and aortic strain (S), pressure strain elastic modulus (Ep), and normalized Ep (Ep*), aortic distensibility (DIS), and beta stiffness index (beta index) were calculated in all subjects.
RESULTS: There was no statistically significant difference between the study and control groups in sex, mean age, body mass index, heart rate, and systolic blood pressure (P > 0.05). However, pulse pressure and left ventricular mass index (LVMI) were found higher in thalassemia major patients compared with the control group. In beta-thalassemia major patients S (0.21 +/- 0.027 vs. 0.26 +/- 0.017, P < 0.0001) and DIS (1.07 +/- 0.25 vs. 1.56 +/- 0.37, P < 0.0001) were significantly lower compared with the control group. However, Ep (196.9 +/- 44.86 vs. 134.20 +/- 29.10, P < 0.0001), Ep* (3.26 +/- 0.98 vs. 2.04 +/- 0.60, P < 0.0001), and beta index (2.44 +/- 0.58 vs. 1.61 +/- 0.37, P < 0.0001) were significantly higher in beta-thalassemia patients than controls. There was a statistically significant negative correlation between LIC and S, DIS. There was also negative correlation between LVMI and S. However, there was a statistically significant positive correlation between LIC and Ep, Ep*.
CONCLUSIONS: Increased abdominal aortic stiffness was detected in beta-thalassemia major patients and this increase in arterial stiffness correlated with LIC and LVMI.
Authors:
Zulal Ulger; Yesim Aydinok; Dolunay Gurses; Erturk Levent; Arif R Ozyurek
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pediatric hematology/oncology     Volume:  28     ISSN:  1077-4114     ISO Abbreviation:  J. Pediatr. Hematol. Oncol.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-10-06     Completed Date:  2007-01-23     Revised Date:  2011-10-06    
Medline Journal Info:
Nlm Unique ID:  9505928     Medline TA:  J Pediatr Hematol Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  647-52     Citation Subset:  IM    
Affiliation:
Department of Pediatric Cardiology, Ege University Hospital, Bornova-Izmir, Turkey. drzulger@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aorta, Abdominal / physiopathology*
Aortic Diseases / complications,  diagnosis*,  physiopathology
Blood Pressure
Child
Elasticity
Female
Humans
Hypertrophy, Left Ventricular / complications,  diagnosis*
Iron / analysis,  blood*
Liver / chemistry,  metabolism,  physiopathology
Male
Predictive Value of Tests
Risk Factors
Sensitivity and Specificity
beta-Thalassemia / blood,  complications,  physiopathology*
Chemical
Reg. No./Substance:
7439-89-6/Iron
Comments/Corrections
Erratum In:
J Pediatr Hematol Oncol. 2006 Nov;28(11):772

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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