Document Detail

Stiff person syndrome.
MedLine Citation:
PMID:  23186907     Owner:  NLM     Status:  In-Data-Review    
Recognizing stiff person syndrome is clinically important. It is uncommon, characterized by body stiffness associated with painful muscle spasms, and varies in location and severity. It is subdivided into stiff trunk versus stiff limb presentation, and as a progressive encephalomyelitis. Stiff person-type syndrome also reflects a paraneoplastic picture. Most patients demonstrate exaggerated lumbar lordosis. Roughly 60% of patients have antiglutamic acid decarboxylase antibodies in the blood and the cerebrospinal fluid. The differential diagnosis includes many severe conditions. There are reports of response to muscle relaxants, immunosuppressants, intravenous gamma globulin, plasma exchange, a number of anticonvulsants, and botulinum toxin.
Giuseppe Ciccoto; Maike Blaya; Roger E Kelley
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurologic clinics     Volume:  31     ISSN:  1557-9875     ISO Abbreviation:  Neurol Clin     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2012-11-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8219232     Medline TA:  Neurol Clin     Country:  United States    
Other Details:
Languages:  eng     Pagination:  319-28     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Inc. All rights reserved.
Department of Neurology, Tulane University School of Medicine, 1430 Tulane Avenue 8065, New Orleans, LA 70112, USA.
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