| Stiff-man syndrome updated. | |
| | |
MedLine Citation:
|
PMID: 2664359 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Stiff-man syndrome, a rare disorder characterized by intermittent spasms and stiffness of the axial muscles, is associated with an electromyographic pattern of continuous motor unit activity in affected muscles. Since the initial description in 1956, the stiff-man syndrome has been reported to occur in various clinical and neurologic settings. In this study, we reviewed the current state of knowledge about this syndrome, defined diagnostic criteria, provided a long-term follow-up of the disorder, and assessed rehabilitative attempts in affected patients. Use of rigorous criteria that identify patients who have the stiff-man syndrome is important because the initial clinical manifestations are similar to those of other neuromuscular diseases. Analysis of 13 patients with stiff-man syndrome examined at the Mayo Clinic during the past 30 years revealed that treatment with diazepam decreased the muscle spasms. Because some muscle spasms usually persist, rehabilitation is an important adjunct that may further improve function when it is centered on the treatment of low-back pain and hyperlordosis, mobility problems, gait abnormalities, and muscular stiffness. |
| | |
Authors:
|
T R Lorish; G Thorsteinsson; F M Howard |
Related Documents
:
|
7202649 - Postural effects of neck muscle vibration in man. 4691429 - 9 -tetrahydrocannabinol: effects on mammalian nonmyelinated nerve fibers. 11445649 - Myopathy with tubulin-reactive crystalline inclusions. 19377419 - Quadriparesis in a young man due to chronic inflammatory demyelinating polyneuropathy. 22925559 - A new device for simultaneous measurement of pelvic floor muscle activity and vaginal b... 16024959 - Rhabdomyolysis induced by psychotropic drugs. 7562829 - Testosterone deficiency myopathy. 9582419 - Calretinin-immunoreactive laminar nerve endings in the laryngeal mucosa of the rat. 10395079 - Mechanisms of resistance to pathogenesis in muscular dystrophies. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Mayo Clinic proceedings. Mayo Clinic Volume: 64 ISSN: 0025-6196 ISO Abbreviation: Mayo Clin. Proc. Publication Date: 1989 Jun |
Date Detail:
|
Created Date: 1989-08-17 Completed Date: 1989-08-17 Revised Date: 2007-10-29 |
Medline Journal Info:
|
Nlm Unique ID: 0405543 Medline TA: Mayo Clin Proc Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 629-36 Citation Subset: AIM; IM |
Affiliation:
|
Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN 55905. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Diagnosis, Differential Diazepam / therapeutic use Electromyography Female Gait Humans Lordosis / complications* Male Middle Aged Muscle Spasticity / complications*, diagnosis, drug therapy Neuromuscular Diseases / diagnosis Spasm / complications Syndrome |
| Chemical | |
Reg. No./Substance:
|
439-14-5/Diazepam |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Mechanisms of drug resistance in acute leukaemia.
Next Document: Obstructive sleep apnea syndrome in patients with class II malocclusion.