Document Detail

Stiff-man syndrome in a woman with breast cancer: an uncommon central nervous system paraneoplastic syndrome.
MedLine Citation:
PMID:  9443464     Owner:  NLM     Status:  MEDLINE    
We report a patient who developed stiff-man syndrome, including disabling shoulder subluxation and wrist ankylosis, in association with breast cancer. Immunologic investigations disclosed autoimmunity directed against not only glutamic acid decarboxylase but also amphiphysin, a 128-kd protein located in the presynaptic compartment of neurons. The patient improved after surgery and corticosteroid treatment and has been stable for nearly 4 years on only anti-estrogenics. The triad of stiff-man syndrome, breast cancer, and autoantibodies against amphiphysin identifies a new autoimmune paraneoplastic syndrome of the CNS.
L Rosin; P DeCamilli; M Butler; M Solimena; H P Schmitt; N Morgenthaler; H M Meinck
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurology     Volume:  50     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  1998 Jan 
Date Detail:
Created Date:  1998-02-06     Completed Date:  1998-02-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  94-8     Citation Subset:  AIM; IM    
Department of Neurology, University of Heidelberg, Germany.
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MeSH Terms
Autoantibodies / blood,  isolation & purification
Blotting, Western
Breast Neoplasms / complications*
Carcinoma, Ductal, Breast / complications*
Diagnosis, Differential
Glutamate Decarboxylase / immunology
Immunoenzyme Techniques
Middle Aged
Nerve Tissue Proteins / immunology
Paraneoplastic Syndromes / complications*,  immunology
Precipitin Tests
Stiff-Person Syndrome / diagnosis,  etiology*,  immunology
Reg. No./Substance:
0/Autoantibodies; 0/Nerve Tissue Proteins; 147954-52-7/amphiphysin; EC Decarboxylase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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