| Stiff-man syndrome in a woman with breast cancer: an uncommon central nervous system paraneoplastic syndrome. | |
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MedLine Citation:
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PMID: 9443464 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report a patient who developed stiff-man syndrome, including disabling shoulder subluxation and wrist ankylosis, in association with breast cancer. Immunologic investigations disclosed autoimmunity directed against not only glutamic acid decarboxylase but also amphiphysin, a 128-kd protein located in the presynaptic compartment of neurons. The patient improved after surgery and corticosteroid treatment and has been stable for nearly 4 years on only anti-estrogenics. The triad of stiff-man syndrome, breast cancer, and autoantibodies against amphiphysin identifies a new autoimmune paraneoplastic syndrome of the CNS. |
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Authors:
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L Rosin; P DeCamilli; M Butler; M Solimena; H P Schmitt; N Morgenthaler; H M Meinck |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neurology Volume: 50 ISSN: 0028-3878 ISO Abbreviation: Neurology Publication Date: 1998 Jan |
Date Detail:
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Created Date: 1998-02-06 Completed Date: 1998-02-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0401060 Medline TA: Neurology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 94-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Neurology, University of Heidelberg, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Autoantibodies / blood, isolation & purification Blotting, Western Breast Neoplasms / complications* Carcinoma, Ductal, Breast / complications* Diagnosis, Differential Female Glutamate Decarboxylase / immunology Humans Immunoenzyme Techniques Middle Aged Nerve Tissue Proteins / immunology Paraneoplastic Syndromes / complications*, immunology Precipitin Tests Rats Stiff-Person Syndrome / diagnosis, etiology*, immunology |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 0/Nerve Tissue Proteins; 147954-52-7/amphiphysin; EC 4.1.1.15/Glutamate Decarboxylase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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