| Stiff-man syndrome. Report of a case. | |
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MedLine Citation:
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PMID: 8203996 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Stiff-man syndrome is a well-described, but rare and often overlooked, neuromuscular syndrome of rigidity, spasm, and gait abnormality that is associated with several endocrinologic and autoimmune disorders. A patient exhibiting many typical features of stiff-man syndrome had intermittent symptoms for 22 years before the correct diagnosis was made. Similar to many described patients, she was diabetic, hyperthyroid, and had elevated islet cell, antithyroid, and glutamic acid decarboxylase antibody levels. The high frequency of diabetes mellitus among patients with stiff-man syndrome is emphasized, as is increasing evidence to suggest that elaboration of anti-glutamic acid decarboxylase and anti-islet cell antibodies may play a role in the pathophysiologic state of the disorder. |
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Authors:
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D Tarsy; E K Miyawaki |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Archives of internal medicine Volume: 154 ISSN: 0003-9926 ISO Abbreviation: Arch. Intern. Med. Publication Date: 1994 Jun |
Date Detail:
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Created Date: 1994-07-05 Completed Date: 1994-07-05 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372440 Medline TA: Arch Intern Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1285-8 Citation Subset: AIM; IM |
Affiliation:
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Division of Neurology, New England Deaconess Hospital, Boston, Mass. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Autoantibodies
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analysis Diabetes Mellitus, Type 1 / complications Female Humans Hyperthyroidism / complications Middle Aged Stiff-Person Syndrome / complications, diagnosis*, immunology |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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