| Sticky nanoparticles: a platform for siRNA delivery by a bis(zinc(II) dipicolylamine)-functionalized, self-assembled nanoconjugate. | |
| | |
MedLine Citation:
|
PMID: 22110006 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Delivering the goods: Multifunctional, self-assembled, polymeric nanoparticles for the simultaneous delivery of small-molecule drugs and siRNA have been synthesized. The nanoparticles are composed of biodegradable hyaluronic acid, for tumor targeting and cellular delivery, and a high siRNA binding affinity is provided by a Zn(II)-dipicolylamine analogue as an artificial phosphate-binding receptor (see scheme). |
| | |
Authors:
|
Gang Liu; Ki Young Choi; Ashwinkumar Bhirde; Magdalena Swierczewska; Juan Yin; Sang Wook Lee; Jae Hyung Park; Jong In Hong; Jin Xie; Gang Niu; Dale O Kiesewetter; Seulki Lee; Xiaoyuan Chen |
Related Documents
:
|
21185716 - Use of a novel micro-fluidic device to create arrays for multiplex analysis of large an... 21428286 - Biophysical probes reveal a "compromise" nature of the methyl-lysine binding pocket in ... 20502526 - Fine definition of the cxcr4-binding region on the v3 loop of feline immunodeficiency v... 20592096 - Genetic and phenotypic characterization of gii-4 noroviruses that circulated during 198... 7214346 - Correlation of induction of aryl hydrocarbon hydroxylase in cultured rat hepatocytes wi... 11583936 - Selective binding of drosophila br-c isoforms to a distal regulatory element in the hsp... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't Date: 2011-11-23 |
Journal Detail:
|
Title: Angewandte Chemie (International ed. in English) Volume: 51 ISSN: 1521-3773 ISO Abbreviation: Angew. Chem. Int. Ed. Engl. Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-04-11 Completed Date: 2012-08-02 Revised Date: 2013-04-12 |
Medline Journal Info:
|
Nlm Unique ID: 0370543 Medline TA: Angew Chem Int Ed Engl Country: Germany |
Other Details:
|
Languages: eng Pagination: 445-9 Citation Subset: IM |
Copyright Information:
|
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
|
Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cell Line Cell Line, Tumor Humans Mice Nanoconjugates / chemistry* Neoplasms / genetics Organometallic Compounds / chemistry* Picolines / chemistry* RNA Interference* RNA, Small Interfering / administration & dosage*, genetics |
| Grant Support | |
ID/Acronym/Agency:
|
R00 CA153772/CA/NCI NIH HHS; Z99 EB999999/EB/NIBIB NIH HHS; ZIA EB000073-03/EB/NIBIB NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Nanoconjugates; 0/Organometallic Compounds; 0/Picolines; 0/RNA, Small Interfering; 0/Zn(II) dipicolylamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Ultrasound-guided botulinum toxin injection: A simple in-office technique to improve tracheoesophage...
Next Document: Differential neural activity in the recognition of old versus new events: An Activation Likelihood E...