Document Detail


Sticky nanoparticles: a platform for siRNA delivery by a bis(zinc(II) dipicolylamine)-functionalized, self-assembled nanoconjugate.
MedLine Citation:
PMID:  22110006     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Delivering the goods: Multifunctional, self-assembled, polymeric nanoparticles for the simultaneous delivery of small-molecule drugs and siRNA have been synthesized. The nanoparticles are composed of biodegradable hyaluronic acid, for tumor targeting and cellular delivery, and a high siRNA binding affinity is provided by a Zn(II)-dipicolylamine analogue as an artificial phosphate-binding receptor (see scheme).
Authors:
Gang Liu; Ki Young Choi; Ashwinkumar Bhirde; Magdalena Swierczewska; Juan Yin; Sang Wook Lee; Jae Hyung Park; Jong In Hong; Jin Xie; Gang Niu; Dale O Kiesewetter; Seulki Lee; Xiaoyuan Chen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't     Date:  2011-11-23
Journal Detail:
Title:  Angewandte Chemie (International ed. in English)     Volume:  51     ISSN:  1521-3773     ISO Abbreviation:  Angew. Chem. Int. Ed. Engl.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-04-11     Completed Date:  2012-08-02     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  0370543     Medline TA:  Angew Chem Int Ed Engl     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  445-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Affiliation:
Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Line
Cell Line, Tumor
Humans
Mice
Nanoconjugates / chemistry*
Neoplasms / genetics
Organometallic Compounds / chemistry*
Picolines / chemistry*
RNA Interference*
RNA, Small Interfering / administration & dosage*,  genetics
Grant Support
ID/Acronym/Agency:
R00 CA153772/CA/NCI NIH HHS; Z99 EB999999/EB/NIBIB NIH HHS; ZIA EB000073-03/EB/NIBIB NIH HHS
Chemical
Reg. No./Substance:
0/Nanoconjugates; 0/Organometallic Compounds; 0/Picolines; 0/RNA, Small Interfering; 0/Zn(II) dipicolylamine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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