Document Detail

Stevioside effect on renal function of normal and hypertensive rats.
MedLine Citation:
PMID:  1434679     Owner:  NLM     Status:  MEDLINE    
Physiological and pharmacological experiments have suggested that stevioside from the leaves of Stevia rebaudiana acts as a typical systemic vasodilator. The effect of stevioside on renal function in both normal and with experimental renal hypertension rats (GII) was evaluated using clearance techniques. Stevioside provoked hypotension, diuresis and natriuresis in both the normal and hypertensive rats. Normal rats presented an increase in renal plasma flow (RPF) and glomerular filtration rate (GFR) constant following stevioside administration. The last effect is in part due to vasodilation of both the afferent and efferent arterioles. Moreover, stevioside infusion in hypertensive rats caused an increase in RPF and GFR. These data are consistent with impairment of a renal autoregulation mechanism in this experimental hypertensive model.
M S Melis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of ethnopharmacology     Volume:  36     ISSN:  0378-8741     ISO Abbreviation:  J Ethnopharmacol     Publication Date:  1992 Jun 
Date Detail:
Created Date:  1992-12-04     Completed Date:  1992-12-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7903310     Medline TA:  J Ethnopharmacol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  213-7     Citation Subset:  IM    
Departamento de Biologia, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Brazil.
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MeSH Terms
Blood Pressure / drug effects
Diterpenes, Kaurane*
Diuresis / drug effects
Glomerular Filtration Rate / drug effects
Glucosides / pharmacology*
Hypertension, Renovascular / physiopathology*
Kidney / blood supply,  drug effects*,  physiology,  physiopathology
Natriuresis / drug effects
Rats, Wistar
Renal Circulation / drug effects
Terpenes / pharmacology*
Vasodilation / drug effects
Reg. No./Substance:
0/Diterpenes; 0/Diterpenes, Kaurane; 0/Glucosides; 0/Terpenes; 57817-89-7/stevioside

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