| Stevens-Johnson syndrome and toxic epidermal necrolysis: a review of treatment options. | |
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MedLine Citation:
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PMID: 21410610 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous reactions that are medication-induced in most instances. While the clinical manifestations of SJS and TEN are well-defined, the optimal treatment for these disorders is not. Case reports have shown benefit with the use of a variety of agents including tumor necrosis factor-alpha inhibitors and cyclophosphamide, whereas thalidomide was associated with an increased mortality. Plasmapheresis and cyclosporine have also demonstrated efficacy anecdotally, albeit with an even smaller number of cases in the literature. Most of the reporting has focused on the use of systemic corticosteroids and intravenous immunoglobulin (IVIG) for these severe reactions. The majority of studies analyzing the use of IVIG in the treatment of SJS/TEN show a benefit, though more recent series cast doubt upon this conclusion. The results of these studies are summarized in this present review study. |
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Authors:
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Scott Worswick; Jonathan Cotliar |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Dermatologic therapy Volume: 24 ISSN: 1529-8019 ISO Abbreviation: Dermatol Ther Publication Date: 2011 Mar-Apr |
Date Detail:
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Created Date: 2011-03-17 Completed Date: 2011-07-07 Revised Date: 2011-08-09 |
Medline Journal Info:
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Nlm Unique ID: 9700070 Medline TA: Dermatol Ther Country: Denmark |
Other Details:
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Languages: eng Pagination: 207-18 Citation Subset: IM |
Copyright Information:
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© 2011 Wiley Periodicals, Inc. |
Affiliation:
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Division of Dermatology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Epidermal Necrolysis, Toxic
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diagnosis,
therapy* Humans Skin / pathology Stevens-Johnson Syndrome / diagnosis, therapy* Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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