| Stevens-Johnson syndrome and toxic epidermal necrolysis-challenges of recognition and management. | |
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MedLine Citation:
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PMID: 11200928 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Skin adverse drug reactions (ADRs) generally present as transient erythematous macular/papular rashes. However these can many a times be the initial presentation of serious muco-cutaneous ADRs such as Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN). The incidence of SJS varies from 1.2 to 6 per million patient-years and that of TEN to be 0.4 to 1.2 per million patient-years. The pathophysiological mechanism of SJS and TEN have not been fully elucidated. The aetiological factors of SJS and TEN are diverse; drugs being the cause in more than 80% cases of TEN and about 40-50% cases of SJS. Mucous membranes are affected in nearly all cases. The extent of epidermal sloughing may vary and forms a basis for the classification of an individual case as SJS or TEN. Prognosis of SJS is better than that of TEN; mortality rates being about 5% and 30%-40% respectively. Specific therapy for these conditions is yet not available. The use of systemic corticosteroids has been controversial. Early diagnoses can prevent/reduce the morbidity of such serious ADRs. This article provides a brief review of the clinical presentation and management of SJS and TEN. |
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Authors:
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S P Sane; A D Bhatt |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: The Journal of the Association of Physicians of India Volume: 48 ISSN: 0004-5772 ISO Abbreviation: J Assoc Physicians India Publication Date: 2000 Oct |
Date Detail:
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Created Date: 2001-01-31 Completed Date: 2001-02-15 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 7505585 Medline TA: J Assoc Physicians India Country: India |
Other Details:
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Languages: eng Pagination: 999-1003 Citation Subset: IM |
Affiliation:
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Novartis India Limited, Medical Department, Khetan Bhavan, 198, J Tata Road, Churchgate, Mumbai-400 020. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Drug Hypersensitivity
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complications*,
diagnosis Epidermal Necrolysis, Toxic / diagnosis*, etiology, therapy* Female Humans India Male Prognosis Risk Assessment Stevens-Johnson Syndrome / diagnosis*, etiology, therapy* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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