Document Detail

Stevens-Johnson syndrome and toxic epidermal necrolysis-challenges of recognition and management.
MedLine Citation:
PMID:  11200928     Owner:  NLM     Status:  MEDLINE    
Skin adverse drug reactions (ADRs) generally present as transient erythematous macular/papular rashes. However these can many a times be the initial presentation of serious muco-cutaneous ADRs such as Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN). The incidence of SJS varies from 1.2 to 6 per million patient-years and that of TEN to be 0.4 to 1.2 per million patient-years. The pathophysiological mechanism of SJS and TEN have not been fully elucidated. The aetiological factors of SJS and TEN are diverse; drugs being the cause in more than 80% cases of TEN and about 40-50% cases of SJS. Mucous membranes are affected in nearly all cases. The extent of epidermal sloughing may vary and forms a basis for the classification of an individual case as SJS or TEN. Prognosis of SJS is better than that of TEN; mortality rates being about 5% and 30%-40% respectively. Specific therapy for these conditions is yet not available. The use of systemic corticosteroids has been controversial. Early diagnoses can prevent/reduce the morbidity of such serious ADRs. This article provides a brief review of the clinical presentation and management of SJS and TEN.
S P Sane; A D Bhatt
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Journal of the Association of Physicians of India     Volume:  48     ISSN:  0004-5772     ISO Abbreviation:  J Assoc Physicians India     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2001-01-31     Completed Date:  2001-02-15     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7505585     Medline TA:  J Assoc Physicians India     Country:  India    
Other Details:
Languages:  eng     Pagination:  999-1003     Citation Subset:  IM    
Novartis India Limited, Medical Department, Khetan Bhavan, 198, J Tata Road, Churchgate, Mumbai-400 020.
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MeSH Terms
Drug Hypersensitivity / complications*,  diagnosis
Epidermal Necrolysis, Toxic / diagnosis*,  etiology,  therapy*
Risk Assessment
Stevens-Johnson Syndrome / diagnosis*,  etiology,  therapy*

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