| Stevens-Johnson syndrome and toxic epidermal necrolysis: what do we know? | |
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MedLine Citation:
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PMID: 20844465 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are rare but severe cutaneous adverse reactions related to a variety of medications. Although rare, SJS and TEN have a significant impact on public health because of high mortality. Also, if the SJS/TEN physiopathology is still unclear, a specific immune response to one or more drugs is involved, constituting a form of delayed-type hypersensitivity. Patients with SJS/TEN are often critically ill; therefore, they must be admitted to hospitals capable of delivering critical care. Currently, no treatment modality has been established as standard for these patients; therefore, therapy is primarily supportive and symptomatic and involves a multidisciplinary approach. |
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Authors:
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Alfredo Tartarone; Rosa Lerose |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Therapeutic drug monitoring Volume: 32 ISSN: 1536-3694 ISO Abbreviation: Ther Drug Monit Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7909660 Medline TA: Ther Drug Monit Country: United States |
Other Details:
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Languages: eng Pagination: 669-72 Citation Subset: IM |
Affiliation:
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Division of Oncology, Centro di Riferimento Oncologico della Basilicata, IRCCS Rionero in Vulture, PZ, Italy. tarta1@virgilio.it |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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