Document Detail


Sterolins ABCG5 and ABCG8: regulators of whole body dietary sterols.
MedLine Citation:
PMID:  16440216     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
ABCG5 and ABCG8 are two ATP-binding cassette half-transporters that belong to the G family members. They were identified as proteins that are mutated in a rare human disorder, sitosterolemia, and their identification led to the completion of the physiological pathways by which dietary cholesterol, as well as noncholesterol sterols, traffics in the mammalian body. These proteins are likely to function as heterodimers, and current evidence suggests that these proteins are responsible for the majority of sterol secretions into bile, thus may define the long sought-after biliary sterol transporters. This review will focus on some of the backgrounds of this physiology, the genetics and regulation of these genes, as well as our current understanding of their functions. This review will also highlight the current limitations in our knowledge gap.
Authors:
Starr E Hazard; Shailendra B Patel
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Publication Detail:
Type:  Journal Article; Review     Date:  2006-01-27
Journal Detail:
Title:  Pflügers Archiv : European journal of physiology     Volume:  453     ISSN:  0031-6768     ISO Abbreviation:  Pflugers Arch.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-01-31     Completed Date:  2007-08-13     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  0154720     Medline TA:  Pflugers Arch     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  745-52     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
ATP-Binding Cassette Transporters / genetics,  physiology*
Amino Acid Sequence
Animals
Cholesterol, Dietary / metabolism
Gene Expression Regulation
Humans
Lipoproteins / genetics,  physiology*
Molecular Sequence Data
Phytosterols / metabolism
Sequence Alignment
Sitosterols / blood
Grant Support
ID/Acronym/Agency:
M01 RR000633/RR/NCRR NIH HHS; R01 HL060613/HL/NHLBI NIH HHS; S10 RR015928/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/ABCG5 protein, human; 0/ABCG8 protein, human; 0/Cholesterol, Dietary; 0/Lipoproteins; 0/Phytosterols; 0/Sitosterols; 5LI01C78DD/gamma-sitosterol
Comments/Corrections

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