| Sterol metabolism and SREBP activation. | |
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MedLine Citation:
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PMID: 20541520 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cholesterol is one of the major components of membrane lipids. Adjustment of the membrane cholesterol balance is, therefore, pivotal in the maintenance of cellular homeostasis. Cholesterol biosynthesis and uptake are tightly regulated at the transcriptional level through a negative feedback control. The transcription factor family known as sterol regulatory element-binding proteins (SREBPs) is in charge of this feedback control. In particular, SREBP-2 is activated in a cholesterol-dependent manner, and hence is deeply involved in regulation of the expression of genes closely related to cholesterol metabolism. Sterol metabolites, including cholesterol, 24,25-dihydrolanosterol and oxysterols, strongly participate in the regulation of sterol metabolism via binding to its particular proteins. |
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Authors:
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Ryuichiro Sato |
Publication Detail:
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Type: Journal Article; Review Date: 2010-06-10 |
Journal Detail:
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Title: Archives of biochemistry and biophysics Volume: 501 ISSN: 1096-0384 ISO Abbreviation: Arch. Biochem. Biophys. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-30 Completed Date: 2010-09-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372430 Medline TA: Arch Biochem Biophys Country: United States |
Other Details:
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Languages: eng Pagination: 177-81 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan. aroysato@mail.ecc.u-tokyo.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Transport, Active Cholesterol / metabolism Cholesterol, HDL / metabolism Endoplasmic Reticulum / metabolism Feedback, Physiological Golgi Apparatus / metabolism Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology Intracellular Signaling Peptides and Proteins / metabolism Liver / drug effects, metabolism Membrane Proteins / metabolism Models, Biological Multiprotein Complexes / metabolism Sterol Regulatory Element Binding Protein 1 / metabolism Sterol Regulatory Element Binding Protein 2 / metabolism Sterol Regulatory Element Binding Proteins / metabolism* Sterols / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, HDL; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Intracellular Signaling Peptides and Proteins; 0/Membrane Proteins; 0/Multiprotein Complexes; 0/SREBP cleavage-activating protein; 0/Sterol Regulatory Element Binding Protein 1; 0/Sterol Regulatory Element Binding Protein 2; 0/Sterol Regulatory Element Binding Proteins; 0/Sterols; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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