Document Detail

Steroids, retinoids, and wound healing.
MedLine Citation:
PMID:  10326344     Owner:  NLM     Status:  MEDLINE    
Glucocorticoids (corticosteroids) cause dehiscence of surgical incisions, increased risk of wound infection, and delayed healing of open wounds. They produce these effects by interfering with inflammation, fibroblast proliferation, collagen synthesis and degradation, deposition of connective tissue ground substances, angiogenesis, wound contraction, and re-epithelialization. These actions are mediated by the antagonism of various growth factors and cytokines. Vitamin A restores the inflammatory response and promotes epithelialization and the synthesis of collagen and ground substances. However, vitamin A does not reverse the detrimental effects of glucocorticoids on wound contraction and infection. In this paper, the known mechanisms of the interaction of glucocorticoids and retinoids are reviewed. The mutually inhibitory interplay between glucocorticoids and retinoids may serve to regulate the processes of inflammation, immunity, and connective tissue repair.
G M Anstead
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Advances in wound care : the journal for prevention and healing     Volume:  11     ISSN:  1076-2191     ISO Abbreviation:  Adv Wound Care     Publication Date:  1998 Oct 
Date Detail:
Created Date:  1999-05-20     Completed Date:  1999-05-20     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9432971     Medline TA:  Adv Wound Care     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  277-85     Citation Subset:  N    
Department of Internal Medicine, University of Texas Health Science Center, San Antonio, USA.
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MeSH Terms
Drug Interactions
Glucocorticoids / adverse effects*
Retinoids / therapeutic use*
Wound Healing / drug effects*
Wounds and Injuries / drug therapy*
Reg. No./Substance:
0/Glucocorticoids; 0/Retinoids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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