| Steroids in the intestinal tract of rats are affected by dietary-fibre-rich barley-based diets. | |
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MedLine Citation:
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PMID: 14667183 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of the present study was to investigate the influence of dietary-fibre (DF)-rich barley-based diets on bile acids (BA) and neutral sterols (NS) in the intestinal tract of rats. For this purpose, young male Wistar rats (n 50; ten per group) weighing about 67 g were fed either a barley-free diet (control group) or diets containing 500 g barley meal extrudates/kg or a barley meal-Novelose mixture (groups A-D) for 6 weeks. These barley products contained 7-24 g resistant starch/100 g and 7-12 g (1 --> 3),(1 --> 4)-beta-glucan/100 g. More steroids were transported towards the lower parts of the intestinal tract when higher concentrations of macromolecular DF were present in the diets (P < 0.001). Tauroconjugated and primary BA dominated in the contents of the small intestine. Intense enzymic conversion of BA occurred in the caecum and colon. The fermentation of DF affected indirectly the amount of formed secondary BA. The main BA present in the caecal contents were muricholic acids, hyodeoxycholic acid and cholic acid. The BA spectrum in the colonic contents was different from that in the caecum. A higher concentration of NS appeared in the intestinal contents of the groups fed the barley-based diets than in the controls (P < 0.005). The microbial conversion of cholesterol to coprostanol, cholestanone and coprostanone was influenced by the amount and composition of the DF in the gut. DF in the diet may affect the concentration and spectrum of steroids in the intestinal tract. The results are relevant for the discussion of mechanisms behind the cholesterol-lowering effects of DF. |
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Authors:
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Gerhard Dongowski; Mario Huth; Erich Gebhardt |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The British journal of nutrition Volume: 90 ISSN: 0007-1145 ISO Abbreviation: Br. J. Nutr. Publication Date: 2003 Nov |
Date Detail:
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Created Date: 2003-12-11 Completed Date: 2004-01-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: England |
Other Details:
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Languages: eng Pagination: 895-906 Citation Subset: IM |
Affiliation:
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Department of Food Chemistry and Preventive Nutrition, German Institute of Human Nutrition, Potsdam-Rehbrücke, Bergholz-Rehbrücke, Germany. dongo@mail.dife.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bile Acids and Salts / metabolism* Cecum / metabolism Cholesterol / metabolism Cholic Acids / metabolism Colon / metabolism Deoxycholic Acid / metabolism Diet / methods* Dietary Fiber / metabolism* Hordeum / metabolism* Intestine, Small / metabolism Intestines / metabolism* Male Rats Rats, Wistar Starch / metabolism Steroids / metabolism* Sterols / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Bile Acids and Salts; 0/Cholic Acids; 0/Steroids; 0/Sterols; 39016-49-4/muricholic acid; 57-88-5/Cholesterol; 83-44-3/Deoxycholic Acid; 83-49-8/hyodeoxycholic acid; 9005-25-8/Starch |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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