Document Detail


Steroids do not alter pancreatic blood supply in hypovolemic dogs: implications on steroid action in acute pancreatitis.
MedLine Citation:
PMID:  3065417     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A recent report from our laboratory showed that pancreatic inflammation induced by hypovolemic shock can be explained to some extent by spoliation in pancreatic perfusion as revealed by electromagnetic flow determinations on the gastroduodenal artery (GDA). On the other hand, when given early in the course of hypovolemic shock, methylprednisolone sodium succinate (MPSS) alleviated pancreatic inflammation as evidenced by gross and histological findings. Five dogs (18-23 kg) were submitted to a 3-hour hypovolemic shock (mean arterial blood pressure, MABP = 50 mm Hg) and received during bleeding 35 mg/kg of MPSS over a 30 min period. Recordings of cardiac output (CO), MABP, regional blood flows in the GDA and superior mesenteric (SMA) arteries were taken every 15 min. The effect of MPSS was appreciated by comparing GDA flow variations in this group with those previously published of a control group comprised of 12 dogs submitted to 3 hours of hypovolemic shock without steroids; operative protocol was in all points similar in both groups. At no time were any significant changes noted when MPSS was added as far as CO and GDA flows were concerned. In other words, the beneficial action of steroids on hypovolemic pancreases cannot be explained by alteration in regional blood flow.
Authors:
J H Robert; A E Toledano; L S Toth; G Premus; D A Dreiling
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of pancreatology : official journal of the International Association of Pancreatology     Volume:  3     ISSN:  0169-4197     ISO Abbreviation:  Int. J. Pancreatol.     Publication Date:  1988 Dec 
Date Detail:
Created Date:  1989-03-22     Completed Date:  1989-03-22     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8703511     Medline TA:  Int J Pancreatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  449-56     Citation Subset:  IM    
Affiliation:
Pancreatic Research Laboratory, Mount Sinai School of Medicine, New York, NY 10029.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Animals
Dogs
Methylprednisolone / analogs & derivatives*
Methylprednisolone Hemisuccinate / therapeutic use*
Pancreas / blood supply*
Pancreatitis / drug therapy,  etiology,  physiopathology*
Shock / complications,  physiopathology*
Splanchnic Circulation*
Chemical
Reg. No./Substance:
2921-57-5/Methylprednisolone Hemisuccinate; 83-43-2/Methylprednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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