| Steroids and aseptic osteonecrosis (AON) in migraine patients. | |
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MedLine Citation:
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PMID: 17445109 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Osteonecrosis is a bony infarction caused by disruption of blood supply to the bone. Aseptic osteonecrosis should be rare with intermittent use of steroids in disabling and refractory migraine cases. We present 3 cases of patients who had severe migraine and developed aseptic osteonecrosis with short-term, intermittent pulse doses of corticosteroids. Migraine has been mentioned as a possible risk factor for aseptic osteonecrosis, and we speculate that severe migraine may be a risk factor for developing aseptic osteonecrosis. Furthermore, migraineurs who develop aseptic osteonecrosis may or may not have associated white matter changes in the brain. We noted a triad of severe migraine, osteonecrosis, and migraine-related white matter lesions in only 1 case. In severe cases of migraine, steroids should be used cautiously. |
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Authors:
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Aamir Hussain; William B Young |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Headache Volume: 47 ISSN: 0017-8748 ISO Abbreviation: Headache Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-04-20 Completed Date: 2007-06-26 Revised Date: 2009-02-02 |
Medline Journal Info:
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Nlm Unique ID: 2985091R Medline TA: Headache Country: United States |
Other Details:
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Languages: eng Pagination: 600-4 Citation Subset: IM |
Affiliation:
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Department of Neurology, Jefferson Headache Center, Thomas Jefferson University, Philadelphia, PA 19107, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Humans Male Middle Aged Migraine Disorders / drug therapy*, pathology Osteonecrosis / chemically induced*, pathology Steroids / adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Steroids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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