Document Detail

Steroids and aseptic osteonecrosis (AON) in migraine patients.
MedLine Citation:
PMID:  17445109     Owner:  NLM     Status:  MEDLINE    
Osteonecrosis is a bony infarction caused by disruption of blood supply to the bone. Aseptic osteonecrosis should be rare with intermittent use of steroids in disabling and refractory migraine cases. We present 3 cases of patients who had severe migraine and developed aseptic osteonecrosis with short-term, intermittent pulse doses of corticosteroids. Migraine has been mentioned as a possible risk factor for aseptic osteonecrosis, and we speculate that severe migraine may be a risk factor for developing aseptic osteonecrosis. Furthermore, migraineurs who develop aseptic osteonecrosis may or may not have associated white matter changes in the brain. We noted a triad of severe migraine, osteonecrosis, and migraine-related white matter lesions in only 1 case. In severe cases of migraine, steroids should be used cautiously.
Aamir Hussain; William B Young
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Headache     Volume:  47     ISSN:  0017-8748     ISO Abbreviation:  Headache     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-20     Completed Date:  2007-06-26     Revised Date:  2009-02-02    
Medline Journal Info:
Nlm Unique ID:  2985091R     Medline TA:  Headache     Country:  United States    
Other Details:
Languages:  eng     Pagination:  600-4     Citation Subset:  IM    
Department of Neurology, Jefferson Headache Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.
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MeSH Terms
Middle Aged
Migraine Disorders / drug therapy*,  pathology
Osteonecrosis / chemically induced*,  pathology
Steroids / adverse effects*
Reg. No./Substance:

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