Document Detail


Steroidal saponins from the aerial parts of Dracaena draco and their cytostatic activity on HL-60 cells.
MedLine Citation:
PMID:  10192965     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Chemical examination of the aerial parts of Dracaena draco has led to the isolation of a total of nine steroidal saponins, including five new ones. The structures of the new saponins were determined by spectral data and a few chemical transformations to be (23S,24S)-spirosta-5,25(27)-diene-1 beta,3 beta,23,24-tetrol 1-O-{O-(2,3,4-tri-O-acetyl-alpha-L-rhamnopyranosyl)-(1-->2)-alpha-L -arabinopyranosyl} 24-O-beta-D-fucopyranoside, (23S,24S)-spirosta-5,25(27)-diene-1 beta,3 beta, 23,24-tetrol 1-O-{O-alpha-L-rhamnopyranosyl-(1-->2)-alpha-L -arabinopyranoside}, (23S,24S)-spirosta-5,25(27)-diene-1 beta,3 beta,23,24-tetrol 1-O-{O-(4-O- acetyl-alpha-L-rhamnopyranosyl)-(1-->2)-alpha-L-arabinopyransoide} , (23S)-spirosta-5,25(27)-diene-1 beta,3 beta,23-triol 1-O-{O-alpha-L- rhamnopyranosyl)-(1-->2)-alpha-L-arabinopyranoside} and (23S,24S)-spirosta-5,25(27)-diene-1 beta,3 beta,23-triol 1-O-{O-(4-O-acetyl-alpha-L-rhamnopyranosyl)-(1-->2)-alpha-L- arabinopyranoside}. The isolated saponins were evaluated for their cytostatic activity on leukemia HL-60 cells.
Authors:
Y Mimaki; M Kuroda; A Ide; A Kameyama; A Yokosuka; Y Sashida
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Phytochemistry     Volume:  50     ISSN:  0031-9422     ISO Abbreviation:  Phytochemistry     Publication Date:  1999 Mar 
Date Detail:
Created Date:  1999-04-30     Completed Date:  1999-04-30     Revised Date:  2006-10-10    
Medline Journal Info:
Nlm Unique ID:  0151434     Medline TA:  Phytochemistry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  805-13     Citation Subset:  IM    
Affiliation:
School of Pharmacy, Tokyo University of Pharmacy and Life Science, Tokyo, Japan. mimakiy@ps.toyaku.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents, Phytogenic / chemistry*,  isolation & purification,  toxicity
Cell Survival / drug effects
HL-60 Cells / drug effects*
Humans
Molecular Conformation
Molecular Structure
Plants, Medicinal*
Saponins / chemistry*,  isolation & purification,  toxicity
Spirostans / chemistry*,  isolation & purification,  toxicity
Chemical
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Saponins; 0/Spirostans

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