Document Detail

Steroidal saponins from the aerial parts of Dracaena draco and their cytostatic activity on HL-60 cells.
MedLine Citation:
PMID:  10192965     Owner:  NLM     Status:  MEDLINE    
Chemical examination of the aerial parts of Dracaena draco has led to the isolation of a total of nine steroidal saponins, including five new ones. The structures of the new saponins were determined by spectral data and a few chemical transformations to be (23S,24S)-spirosta-5,25(27)-diene-1 beta,3 beta,23,24-tetrol 1-O-{O-(2,3,4-tri-O-acetyl-alpha-L-rhamnopyranosyl)-(1-->2)-alpha-L -arabinopyranosyl} 24-O-beta-D-fucopyranoside, (23S,24S)-spirosta-5,25(27)-diene-1 beta,3 beta, 23,24-tetrol 1-O-{O-alpha-L-rhamnopyranosyl-(1-->2)-alpha-L -arabinopyranoside}, (23S,24S)-spirosta-5,25(27)-diene-1 beta,3 beta,23,24-tetrol 1-O-{O-(4-O- acetyl-alpha-L-rhamnopyranosyl)-(1-->2)-alpha-L-arabinopyransoide} , (23S)-spirosta-5,25(27)-diene-1 beta,3 beta,23-triol 1-O-{O-alpha-L- rhamnopyranosyl)-(1-->2)-alpha-L-arabinopyranoside} and (23S,24S)-spirosta-5,25(27)-diene-1 beta,3 beta,23-triol 1-O-{O-(4-O-acetyl-alpha-L-rhamnopyranosyl)-(1-->2)-alpha-L- arabinopyranoside}. The isolated saponins were evaluated for their cytostatic activity on leukemia HL-60 cells.
Y Mimaki; M Kuroda; A Ide; A Kameyama; A Yokosuka; Y Sashida
Related Documents :
12006175 - Differential modulation by exogenous carbon monoxide of tnf-alpha stimulated mitogen-ac...
11546645 - Regulation and distribution of madcam-1 in endothelial cells in vitro.
15994315 - Protein phosphatase 2a regulates apoptosis in intestinal epithelial cells.
3165095 - Stimulation by tumor necrosis factor of hl-60 thymidine salvage pathway metabolism diss...
21044075 - Regulation and role of cyclin-dependent kinase activity in neuronal survival and death.
16081635 - Analysis of the biochemical mechanisms for the endocrine actions of fibroblast growth f...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Phytochemistry     Volume:  50     ISSN:  0031-9422     ISO Abbreviation:  Phytochemistry     Publication Date:  1999 Mar 
Date Detail:
Created Date:  1999-04-30     Completed Date:  1999-04-30     Revised Date:  2006-10-10    
Medline Journal Info:
Nlm Unique ID:  0151434     Medline TA:  Phytochemistry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  805-13     Citation Subset:  IM    
School of Pharmacy, Tokyo University of Pharmacy and Life Science, Tokyo, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antineoplastic Agents, Phytogenic / chemistry*,  isolation & purification,  toxicity
Cell Survival / drug effects
HL-60 Cells / drug effects*
Molecular Conformation
Molecular Structure
Plants, Medicinal*
Saponins / chemistry*,  isolation & purification,  toxicity
Spirostans / chemistry*,  isolation & purification,  toxicity
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Saponins; 0/Spirostans

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Molecular authentication of Panax species.
Next Document:  Two bioactive mono-tetrahydrofuran acetogenins, annoglacins A and B, from Annona glabra.