| Steroidal saponins from Fritillaria pallidiflora Schrenk. | |
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MedLine Citation:
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PMID: 22450263 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Five new steroidal saponins, Pallidifloside D (1), Pallidifloside E (2), Pallidifloside G (5), Pallidifloside H (6) and Pallidifloside I (7), together with seven other steroidal saponins (3, 4, 8-12) were isolated from the dry bulbs of Fritillaria pallidiflora Schrenk. Their structures were established by spectroscopic techniques (IR, MS, 1D and 2D NMR) and chemical means. The isolated steroidal saponins were evaluated for cyotoxic activity against human C6 brain gliomas and Hela cervix cancer cell lines using MTT assays. Compounds 1, 10, 11, 12 showed cytotoxicity against C6 and Hela cell lines with IC(50) values in the range of 5.1-75.8μM. |
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Authors:
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Shuo Shen; Guoyu Li; Jian Huang; Chaojun Chen; Bu Ren; Ga Lu; Yong Tan; Jiaxu Zhang; Xian Li; Jinhui Wang |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-3-16 |
Journal Detail:
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Title: Fitoterapia Volume: - ISSN: 1873-6971 ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-3-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 16930290R Medline TA: Fitoterapia Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012. Published by Elsevier B.V. |
Affiliation:
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School of Traditional Chinese Materia Medica 49(#), Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, PR China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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