Document Detail


Steroidal glycosides from Furcraea foetida and their cytotoxic activity.
MedLine Citation:
PMID:  19801882     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two new spirostanol glycosides (1, 2) and a new furostanol glycoside (3), together with nine known steroidal glycosides (4-12) were isolated from the leaves of Furcraea foetida (Agavaceae). The structures of the new compounds were determined by spectroscopic analysis and the results of hydrolytic cleavage. The isolated compounds were evaluated for their cytotoxic activities against HL-60 human leukemia cells, A549 human lung adenocarcinoma cells, HSC-2 human oral squamous carcinoma cells, and HSC-4 human oral squamous carcinoma cells.
Authors:
Akihito Yokosuka; Tomoe Sano; Ken Hashimoto; Hiroshi Sakagami; Yoshihiro Mimaki
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chemical & pharmaceutical bulletin     Volume:  57     ISSN:  1347-5223     ISO Abbreviation:  Chem. Pharm. Bull.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-05     Completed Date:  2009-12-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0377775     Medline TA:  Chem Pharm Bull (Tokyo)     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1161-6     Citation Subset:  IM    
Affiliation:
Laboratory of Medicinal Pharmacognosy, Tokyo University of Pharmacy and Life Sciences School of Pharmacy, Hachiouji, Tokyo 192-0392, Japan. yokosuka@toyaku.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Agavaceae / chemistry*
Antineoplastic Agents, Phytogenic / chemistry*,  isolation & purification,  toxicity
Cell Line, Tumor
Drug Screening Assays, Antitumor
Glycosides / chemistry*,  isolation & purification,  toxicity
HL-60 Cells
Humans
Magnetic Resonance Spectroscopy
Molecular Conformation
Spirostans / chemistry*,  isolation & purification,  toxicity
Chemical
Reg. No./Substance:
0/(23S,25R)-6alpha-((beta-D-glucopyranosyl)oxy)-23-hydroxy-5alpha-spirostan-3beta -yl beta -D-fucopyranoside; 0/Antineoplastic Agents, Phytogenic; 0/Glycosides; 0/Spirostans

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