Document Detail

Steroidal control of rat uterine 17 beta-hydroxysteroid dehydrogenase activity.
MedLine Citation:
PMID:  6932105     Owner:  NLM     Status:  MEDLINE    
The interconversion of estradiol-17 beta and estrone in the rat uterus is due to the action of 17 beta-hydroxysteroid dehydrogenase. Whole uteri or 800 x g supernatant fractions of the uteri were incubated in the presence of [3H] estradiol-17 beta and NAD at 37 degrees C for 3 h or 1 h, respectively. In the mature rat uterus the oxidation of estradiol-17 beta and estrone was dependent on the stage of the estrous cycle, suggesting hormonal control. The 17 beta-hydroxysteroid dehydrogenase activity was highest at estrus (200 fmol estrone) and lowest at diestrus (80 fmol estrone). An enhancement of activity occurred when adult rats at each stage of the estrous cycle were administered estradiol-17 beta, while progesterone administration at each stage resulted in decreased enzyme activity. The uterine 17 beta-hydroxysteroid dehydrogenase activity of estradiol-17 beta treated ovariectomized rats was time and dose dependent but decreased when progesterone was administered with or without estradiol-17 beta administration. These results suggest that estradiol-17 beta caused an increase in enzyme activity that was inhibitable by progesterone in the rat uterus. The increased 17 beta-hydroxysteroid dehydrogenase activity may reflect a specific response of the rat uterus to estradiol-17 beta.
R Wahawisan; T A Gorell
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Steroids     Volume:  36     ISSN:  0039-128X     ISO Abbreviation:  Steroids     Publication Date:  1980 Jul 
Date Detail:
Created Date:  1980-11-20     Completed Date:  1980-11-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404536     Medline TA:  Steroids     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  115     Citation Subset:  IM    
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MeSH Terms
17-Hydroxysteroid Dehydrogenases / metabolism*,  pharmacology
Estradiol / pharmacology
Progesterone / pharmacology
Steroids / pharmacology*
Substance Withdrawal Syndrome / enzymology
Uterus / drug effects,  enzymology*
Reg. No./Substance:
0/Steroids; 50-28-2/Estradiol; 57-83-0/Progesterone; EC 1.1.-/17-Hydroxysteroid Dehydrogenases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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