Document Detail


Steroidal Alkaloids from the Marine Sponge Corticium niger That Inhibit Growth of Human Colon Carcinoma Cells.
MedLine Citation:
PMID:  25338277     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Bioinformatic analysis of data from the NCI-60 cell cytotoxicity screen revealed a subset of extracts that showed selective cytotoxic activity toward human colon carcinoma cell lines. Bioassay-guided fractionation of a colon cancer selective extract from a Philippines collection of the marine sponge Corticium niger provided two new steroidal alkaloids, plakinamines N (1) and O (2), along with two known compounds of the plakinamine class (3, 4). The structures of these compounds were elucidated by interpretation of combined MS and NMR spectroscopic data. Plakinamines N (1), O (2), and J (4) were tested for antiproliferative activity in the NCI-60 screen, and they showed enhanced inhibitory effects against all of the colon cell lines with mean GI50 values of 11.5, 2.4, and 1.4 μM, respectively.
Authors:
Suthananda N Sunassee; Tanya Ransom; Curtis J Henrich; John A Beutler; David G Covell; James B McMahon; Kirk R Gustafson
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Publication Detail:
Type:  Journal Article     Date:  2014-10-22
Journal Detail:
Title:  Journal of natural products     Volume:  77     ISSN:  1520-6025     ISO Abbreviation:  J. Nat. Prod.     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-11-26     Completed Date:  -     Revised Date:  2014-12-04    
Medline Journal Info:
Nlm Unique ID:  7906882     Medline TA:  J Nat Prod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2475-80     Citation Subset:  IM    
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