| Steroid withdrawal in living donor renal transplant recipients using tacrolimus and cyclosporine: a randomized prospective study. | |
| | |
MedLine Citation:
|
PMID: 16771869 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Steroids have been a mainstay of immunosuppressive regimens in renal transplantation despite their adverse effects. The introduction of new immunosuppressant has improved the survival rates and prompted trials of steroid withdrawal. We conducted a randomized prospective study to compare steroid withdrawal at 6 months post-transplant between tacrolimus + mycophenolate mofetil (MMF) (FK group) versus cyclosporine A + MMF (CsA group). Steroid was withdrawn at 6 months post-transplant under the condition of no rejection episode proven by biopsy and maintenance of serum creatinine level <2.0 mg/dl. Fourteen recipients were excluded because of acute rejection within 6 months or protocol violation. Steroid could be tapered off in 62 in FK group and 55 in CsA. Three cases in FK group and five in CsA had acute rejection within another 6 months after steroid withdrawal (P > 0.05). At 12 months, the incidence of post-transplant diabetes was 18.6% vs. 8.0% in FK and CsA group. And hypercholesterolemia was presented in 8.5% vs. 2.0%, hypertension in 47.5% vs. 56.0%, and serum creatinine level 1.18 +/- 0.24 mg/dl vs. 1.18 +/- 0.20 mg/dl, respectively (P > 0.05). Steroid withdrawal may be carried out successfully using both FK and CsA with MMF, but long-term follow-up is necessary. |
| | |
Authors:
|
Jae Berm Park; Sung-Joo Kim; Ha Young Oh; Young Seok Han; Doo Jin Kim; Jin Wan Park; Choon Hyuck Kwon; Jae-Won Joh; Suk-Koo Lee |
Related Documents
:
|
16858279 - Combination effect of mycophenolate mofetil with mizoribine on cell proliferation assay... 16213289 - Mycophenolate mofetil in pediatric renal transplantation. 16447209 - Cyclosporine a withdrawal during follow-up after pediatric liver transplantation. 15518749 - Efficacy of mycophenolate mofetil versus azathioprine after renal transplantation: a sy... 15267179 - Progressive bilateral sensorineural hearing loss probably induced by chronic cyclospori... 12461659 - Long-term results of a prospective randomized study comparing two immunosuppressive reg... 6727139 - Erythropoietin deficiency and inhibition of erythropoiesis in renal insufficiency. 17720989 - Incidence of biopsy-proven glomerulonephritis. 18557719 - The chemokine receptor cxcr3 is not essential for acute cardiac allograft rejection in ... |
Publication Detail:
|
Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Transplant international : official journal of the European Society for Organ Transplantation Volume: 19 ISSN: 0934-0874 ISO Abbreviation: Transpl. Int. Publication Date: 2006 Jun |
Date Detail:
|
Created Date: 2006-06-14 Completed Date: 2006-07-31 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8908516 Medline TA: Transpl Int Country: Germany |
Other Details:
|
Languages: eng Pagination: 478-84 Citation Subset: IM |
Affiliation:
|
Department of Surgery, Samsung Medical Center, Sungkyunkwan University, School of Medicine, Seoul, Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Cyclosporine / pharmacology* Female Humans Immunosuppressive Agents / pharmacology Kidney Transplantation / methods* Living Donors Male Middle Aged Prospective Studies Steroids / metabolism, pharmacology* Tacrolimus / pharmacology* |
| Chemical | |
Reg. No./Substance:
|
0/Immunosuppressive Agents; 0/Steroids; 109581-93-3/Tacrolimus; 59865-13-3/Cyclosporine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Solitary pancreas transplantation for life-threatening allergy to human insulin.
Next Document: Monolateral placement of both kidneys in dual kidney transplantation: low surgical complication rate...