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Steroid sulfatase is a potential modifier of cognition in Attention Deficit Hyperactivity Disorder.
MedLine Citation:
PMID:  21232013     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Deletions encompassing the X-linked STS gene (encoding steroid sulfatase) have been observed in subjects with neurodevelopmental disorders, including Attention Deficit Hyperactivity Disorder (ADHD). Recently, two single nucleotide polymorphisms (SNPs) within STS (rs12861247 and rs17268988) have been reported to be associated with ADHD risk and inattentive symptoms in ADHD respectively. Using a UK sample of ADHD subjects (aged 5-18 years), we tested the hypothesis that rs12861247 is associated with ADHD risk using a case-control approach (comparing 327 ADHD cases with 358 male controls from the Wellcome Trust Case Control Consortium). Using a subset of males from the ADHD sample, we also examined whether variation within STS is associated with symptomatology/cognitive function in ADHD. We then tested whether SNPs associated with cognitive function in ADHD were also associated with cognitive function in healthy male subjects using a German sample (n = 143, aged 18-30 years), and whether STS was expressed in brain regions pertinent to ADHD pathology during development. We did not replicate the previously identified association with rs12861247. However, in ADHD males, variation at rs17268988 was associated with inattentive symptoms, whilst variation within STS was significantly associated with performance on three cognitive measures. Three SNPs associated with cognitive function in ADHD males were not associated with cognitive function in healthy males. STS was highly expressed in the developing cerebellar neuroepithelium, basal ganglia, thalamus, pituitary gland, hypothalamus and choroid plexus. These data suggest that genetic variants affecting steroid sulfatase expression and/or activity could influence the function of brain regions perturbed in ADHD.
Authors:
E Stergiakouli; K Langley; H Williams; J Walters; N M Williams; S Suren; I Giegling; L S Wilkinson; M J Owen; M C O'Donovan; D Rujescu; A Thapar; W Davies
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-13
Journal Detail:
Title:  Genes, brain, and behavior     Volume:  -     ISSN:  1601-183X     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101129617     Medline TA:  Genes Brain Behav     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 The Authors. Journal compilation © 2011 Blackwell Publishing Ltd/International Behavioural and Neural Genetics Society.
Affiliation:
MRC Centre for Neuropsychiatric Genetics and Genomics and Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, CF14 4XN, U.K. School of Psychology, Cardiff University, Cardiff, CF10 3AT, U.K. Human Developmental Biology Resource, University College London Institute of Child Health, London, WC1N 1EH, U.K. Section of Molecular and Clinical Neurobiology, Department of Psychiatry, Ludwig Maximilians University, Nussbaumstrasse 7, 80336 Munich, Germany Behavioural Genetics Group, Schools of Medicine and Psychology, Cardiff University, Cardiff, UK.
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