Document Detail

Steroid responsiveness in a case of Riedel's thyroiditis and retroperitoneal fibrosis.
MedLine Citation:
PMID:  15117103     Owner:  NLM     Status:  MEDLINE    
Riedel's thyroiditis is a rare chronic inflammatory disease of the thyroid characterised by an invasive fibrotic process. We present a lady with newly diagnosed hypothyroidism, rapidly enlarging hard, fixed goitre, strongly positive thyroid antibodies and raised erythrocyte sedimentation rate (ESR). A tru-cut biopsy confirmed Riedel's struma. Regression of the goitre and reduction of antibody titres occurred after starting prednisolone, which was stopped after 10 months. Six months later, she presented with renal failure due to retroperitoneal fibrosis that was successfully treated by reinstitution of steroids and ureteric stenting. Very high titres of thyroid antibodies and hypothyroidism predating development of goitre suggest coexistence of Hashimoto's thyroiditis and Riedel's thyroiditis. Tru-cut biopsy obviated the need for open thyroidectomy. A predominantly inflammatory as opposed to fibrotic thyroid histology may predict good response to steroids. Relapse following steroid withdrawal may not only be in the thyroid but also at other sites.
P K Moulik; M S Al-Jafari; A A Khaleeli
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  International journal of clinical practice     Volume:  58     ISSN:  1368-5031     ISO Abbreviation:  Int. J. Clin. Pract.     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-04-30     Completed Date:  2004-07-06     Revised Date:  2007-02-14    
Medline Journal Info:
Nlm Unique ID:  9712381     Medline TA:  Int J Clin Pract     Country:  England    
Other Details:
Languages:  eng     Pagination:  312-5     Citation Subset:  IM    
Department of Medicine, Halton General Hospital, Runcorn, UK.
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MeSH Terms
Glucocorticoids / therapeutic use*
Middle Aged
Prednisolone / therapeutic use*
Retroperitoneal Fibrosis / drug therapy*,  radiography
Thyroiditis / drug therapy*,  radiography
Thyroiditis, Autoimmune / drug therapy
Tomography, X-Ray Computed
Reg. No./Substance:
0/Glucocorticoids; 50-24-8/Prednisolone

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