| Steroid response in moderate to severe pediatric ulcerative colitis: a single center's experience. | |
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MedLine Citation:
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PMID: 21191776 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND: we aimed to analyze clinical and inflammatory markers of steroid non-response in patients with moderate/severe ulcerative colitis (UC) at the time of diagnosis. METHODS: this study included patients who were graded as having moderate/severe UC and received corticosteroids as first-line therapy. Demographic, clinical and laboratory findings and pediatric ulcerative colitis activity scores (PUCAS) were recorded. Response to corticosteroids was assessed 30 days after the induction and long-term therapy. RESULTS: twenty-eight children were diagnosed as having moderate/severe UC. Their mean age ± SD was 1 2.2 ± 4 years, and 17% were under 5 years of age. PUCAS at their initial admission was 56.9 ± 11.8. UC was observed at the left colon in 9 patients (32.1%), and pancolitis in 19 (67.9%). At the end of the 30th day, UC was completely remitted in 15 patients (53.5%), partially remitted in 2 (7.1%), and no response in 11 (39.2%). Short-term follow-up showed partial remission in 2 patients, and overall remission with steroid in 17 (60.7%). Non-responders were given second-line treatment; steroid dependency was documented in 2 patients (7.1%) and another 2 (7.1%) patients underwent colectomy. Predictors for steroid non-response were analyzed and only PUCAS at the initial admission was found to be associated with non-response to steroids (51.4 ± 11.4 vs. 65.4 ± 6.8, P<0.05). CONCLUSIONS: approximately half of the pediatric patients had complete response to steroid therapy in a long period. PUCAS could be used as a potential marker of "failed response" to steroid, but should be supported with a number of prospective randomized controlled studies. |
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Authors:
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Murat Cakir; Funda Ozgenc; Hasan Ali Yusekkaya; Cigdem Omur Ecevit; Rasit Vural Yagci |
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Publication Detail:
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Type: Journal Article Date: 2010-12-30 |
Journal Detail:
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Title: World journal of pediatrics : WJP Volume: 7 ISSN: 1867-0687 ISO Abbreviation: World J Pediatr Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2010-12-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101278599 Medline TA: World J Pediatr Country: China |
Other Details:
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Languages: eng Pagination: 50-3 Citation Subset: IM |
Affiliation:
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Faculty of Medicine, Department of Pediatric Gastroenterology, Hepatology and Nutrition, Ege University, Bornova, Izmir, Turkey. muratcak@hotmail.com |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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