| Steroid resistance in nasal polyposis: role of glucocorticoid receptor and TGF-beta1. | |
| | |
MedLine Citation:
|
PMID: 23193535 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
BACKGROUND: Glucocorticoids (GCs) are considered drugs of choice for treating nasal polyps (NPs). However, a subset of patients shows a limited clinical response even to high doses of GCs. Altered expression of glucocorticoid receptors (GRs), namely GR-alpha; and GR-beta;, is a potential mechanism underlying GC insensitivity. GCs modulate the expression of several cytokines, including transforming growth factor-beta (TGF-beta), which may contribute to cellular proliferation in NPs. The study investigates some biomolecular features of GC-resistant NPs, and examines possible differences from normal mucosa (NM). METHODOLOGY: Radioligand binding assay (binding) was used to determine GR-alpha; binding capacity; Western blotting was used to evaluate GR-alpha;, GR-beta;, and TGF-beta; expression and GR-alpha; subcellular distribution. NPs were sampled in 32 patients during ethmoidectomy; NM was taken from 15 healthy patients during rhinoplasty. RESULTS: GR-alpha; was present in NPs and NM, with lower affinity for the ligand in NPs. GR-alpha; was prevalent in the cytosol of NPs that were GR-alpha-negative to the binding assay. GR-beta was expressed in NPs and absent in the majority of NM. TGF-beta1 expression was higher in NPs than in NM. CONCLUSIONS: GR-beta and TGF-beta1 might be involved in NP pathogenesis, but their role in modulating GC sensitivity is still unclear. |
| | |
Authors:
|
S Aversa; C Ondolo; G Abbadessa; F Piccione; V Carriero; A Fulcheri; A Lauria; S De Francia; S Racca |
Related Documents
:
|
23229005 - Expression of the androgen receptor in the testis of mice with a sertoli cell specific ... 12594235 - Stem cell factor attenuates liver damage in a murine model of acetaminophen-induced hep... 6971745 - Influence of antithymocytic serum on the regenerating activity of the liver after parti... 22960105 - Endogenous cntf mediates stroke-induced adult cns neurogenesis in mice. 19204515 - Tetrandrine increased the survival rate of mice with lipopolysaccharide-induced endotox... 19181855 - Tissue plasminogen activator modulates the cellular and behavioral response to cocaine. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Rhinology Volume: 50 ISSN: 0300-0729 ISO Abbreviation: Rhinology Publication Date: 2012 Dec |
Date Detail:
|
Created Date: 2012-11-29 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0347242 Medline TA: Rhinology Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 427-35 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Clinical efficacy of a dry extract of five herbal drugs in acute viral rhinosinusitis.
Next Document: A near single crystalline TiO(2) nanohelix array: enhanced gas sensing performance and its applicati...