| Steroid receptors in breast cancer patients. Influence of obesity and age at diagnosis. | |
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MedLine Citation:
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PMID: 1503426 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The influence of host age on estrogen (ER) and progesterone (PR) receptor status was studied in 603 tumors obtained from women with confirmed diagnosis of breast carcinoma. Both ER and PR analysis were performed in our own laboratory using standard techniques. Tumors were classified as positive if minimum receptor contents were greater than 10 fmol/mg cytosol protein and if dissociation constants were 1-9 x 10(-10) M or lower. Data from our study indicate that the incidence of receptor negative (ER-PR-) tumors was higher in women from 21 to 40 years of age than in women from 41 to 60 years of age. In women over 60 years of age, the incidence of ER+PR+ tumors was higher than in women under 40 years of age. Interestingly, women from 51 to 60 years of age had a significantly lower incidence (P less than 0.06, 0.0001) of ER+PR+ but higher incidence (P less than 0.01) of ER-PR- tumors than women 41-50 or greater than 60 years of age. Analysis of steroid receptor distribution in relation to host age and obesity showed a definite tendency: in obese women over 60 years of age, frequency of ER+PR+ was significantly greater than in non-obese women of similar age groups. This altered ER and PR distribution in tumors is probably a result of difference in the hormonal milieu associated with host menopausal status and obesity. |
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Authors:
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R R Mehta; G Hart; T K Das Gupta |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Anticancer research Volume: 12 ISSN: 0250-7005 ISO Abbreviation: Anticancer Res. Publication Date: 1992 Jul-Aug |
Date Detail:
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Created Date: 1992-09-17 Completed Date: 1992-09-17 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8102988 Medline TA: Anticancer Res Country: GREECE |
Other Details:
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Languages: eng Pagination: 1311-4 Citation Subset: IM |
Affiliation:
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Specialized Center for Cancer Research and Education, University of Illinois, Chicago 60612. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Aged Aged, 80 and over Breast Neoplasms / chemistry* Female Humans Middle Aged Obesity / metabolism* Receptors, Estrogen / analysis*, metabolism Receptors, Progesterone / analysis*, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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P01 CA 31827/CA/NCI NIH HHS; R29 CA 46423/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Estrogen; 0/Receptors, Progesterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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