Document Detail


Steroid receptors and endometrial cancer.
MedLine Citation:
PMID:  3539444     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Like breast carcinomas, endometrial carcinomas are derived from sex steroid target tissue. Progress and research directed into the clinicopathologic relationship of steroid receptors and endometrial carcinomas have been hampered by many factors, including: limited numbers of patients with advanced-stage disease compared to the number with breast carcinoma; contamination of specimens with surrounding benign endometrial components which may contribute to total steroid binding; and amount of tissue required for standard biochemical assays. Nevertheless, several clinicopathological associations have been made for steroid receptor content of endometrial carcinomas. Receptor content appears to correlate with histological differentiation in that well-differentiated lesions have higher mean levels of receptor and more receptor 'positive' lesions than do poorly differentiated lesions. Furthermore, receptor levels and status appear to correlate with prognosis of primary endometrial carcinomas and response to hormonal therapy of advanced endometrial carcinoma. Newer techniques utilizing monoclonal antibodies to directly localize receptor in tissue specimens may lead to a greater understanding of the dynamics of receptor physiology in endometrial carcinomas, and may make possible more accurate predictions of clinical behavior by allowing the direct analysis of the receptor content of the malignant component within a tissue specimen.
Authors:
J T Soper; C W Christensen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinics in obstetrics and gynaecology     Volume:  13     ISSN:  0306-3356     ISO Abbreviation:  Clin Obstet Gynaecol     Publication Date:  1986 Dec 
Date Detail:
Created Date:  1987-02-12     Completed Date:  1987-02-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7509601     Medline TA:  Clin Obstet Gynaecol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  825-42     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Antibodies, Monoclonal / diagnostic use
Endometrium / pathology
Female
Humans
Immunoenzyme Techniques
Neoplasm Invasiveness
Progesterone Congeners / therapeutic use
Prognosis
Receptors, Estrogen / analysis*
Receptors, Progesterone / analysis*
Research
Uterine Neoplasms / analysis,  drug therapy,  pathology
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Progesterone Congeners; 0/Receptors, Estrogen; 0/Receptors, Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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