Document Detail


Steroid receptor coactivator 3 regulates autophagy in breast cancer cells through macrophage migration inhibitory factor.
MedLine Citation:
PMID:  22430150     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
SRC-3/AIB1 (steroid receptor coactivator 3/amplified in breast cancer 1) is an authentic oncogene that contributes to the development of drug resistance and poor disease-free survival in cancer patients. Autophagy is also an important cell death mechanism that has tumor suppressor function. In this study, we identified macrophage migration inhibitory factor (MIF) as a novel target gene of SRC-3 and demonstrated its importance in cell survival. Specifically, we showed that MIF is a strong suppressor of autophagic cell death. We further showed that suppression of MIF, in turn, induced autophagic cell death, enhanced chemosensitivity and inhibited tumorigenesis in a xenograft mouse tumorigenesis model. Our study demonstrated that regulation of MIF expression and suppression of autophagic cell death is a potent mechanism by which SRC-3 contributes to increased chemoresistance and tumorigenicity.
Authors:
Mei-Yi Wu; Junjiang Fu; Jianming Xu; Bert W O'Malley; Ray-Chang Wu
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-03-20
Journal Detail:
Title:  Cell research     Volume:  22     ISSN:  1748-7838     ISO Abbreviation:  Cell Res.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-04     Completed Date:  2012-09-24     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  9425763     Medline TA:  Cell Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  1003-21     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Autophagy*
Breast Neoplasms / drug therapy,  metabolism,  pathology
Cell Hypoxia
Cell Line, Tumor
Cell Survival
Female
HEK293 Cells
HeLa Cells
Humans
Hypoxia-Inducible Factor 1, alpha Subunit / metabolism
I-kappa B Kinase / metabolism
Macrophage Migration-Inhibitory Factors / antagonists & inhibitors,  genetics,  metabolism*
Mice
Nuclear Receptor Coactivator 3 / antagonists & inhibitors,  genetics,  metabolism*
Peptide Fragments / metabolism
Phosphorylation
Promoter Regions, Genetic
RNA Interference
RNA, Small Interfering / metabolism,  therapeutic use
Sialoglycoproteins / metabolism
Transplantation, Heterologous
Grant Support
ID/Acronym/Agency:
R01 CA112403/CA/NCI NIH HHS; R01 CA119689/CA/NCI NIH HHS; R01 HD007857/HD/NICHD NIH HHS; R01 HD008188/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Hypoxia-Inducible Factor 1, alpha Subunit; 0/Macrophage Migration-Inhibitory Factors; 0/Peptide Fragments; 0/RNA, Small Interfering; 0/Sialoglycoproteins; 0/bone sialoprotein (35-62), human; EC 2.3.1.48/Nuclear Receptor Coactivator 3; EC 2.7.11.10/I-kappa B Kinase
Comments/Corrections
Comment In:
Cell Res. 2012 Jun;22(6):950-3   [PMID:  22565285 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Early development in the velvet worm Euperipatoides kanangrensis Reid 1996 (Onychophora: Peripatopsi...
Next Document:  Laminin/?1 integrin signal triggers axon formation by promoting microtubule assembly and stabilizati...