| Steroid receptor coactivator 3 regulates autophagy in breast cancer cells through macrophage migration inhibitory factor. | |
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MedLine Citation:
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PMID: 22430150 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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SRC-3/AIB1 (steroid receptor coactivator 3/amplified in breast cancer 1) is an authentic oncogene that contributes to the development of drug resistance and poor disease-free survival in cancer patients. Autophagy is also an important cell death mechanism that has tumor suppressor function. In this study, we identified macrophage migration inhibitory factor (MIF) as a novel target gene of SRC-3 and demonstrated its importance in cell survival. Specifically, we showed that MIF is a strong suppressor of autophagic cell death. We further showed that suppression of MIF, in turn, induced autophagic cell death, enhanced chemosensitivity and inhibited tumorigenesis in a xenograft mouse tumorigenesis model. Our study demonstrated that regulation of MIF expression and suppression of autophagic cell death is a potent mechanism by which SRC-3 contributes to increased chemoresistance and tumorigenicity. |
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Authors:
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Mei-Yi Wu; Junjiang Fu; Jianming Xu; Bert W O'Malley; Ray-Chang Wu |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-03-20 |
Journal Detail:
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Title: Cell research Volume: 22 ISSN: 1748-7838 ISO Abbreviation: Cell Res. Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-06-04 Completed Date: 2012-09-24 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 9425763 Medline TA: Cell Res Country: England |
Other Details:
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Languages: eng Pagination: 1003-21 Citation Subset: IM |
Affiliation:
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Department of Biochemistry and Molecular Biology, George Washington University, Washington, DC 20037, USA. bcmmxw@gwumc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Autophagy* Breast Neoplasms / drug therapy, metabolism, pathology Cell Hypoxia Cell Line, Tumor Cell Survival Female HEK293 Cells HeLa Cells Humans Hypoxia-Inducible Factor 1, alpha Subunit / metabolism I-kappa B Kinase / metabolism Macrophage Migration-Inhibitory Factors / antagonists & inhibitors, genetics, metabolism* Mice Nuclear Receptor Coactivator 3 / antagonists & inhibitors, genetics, metabolism* Peptide Fragments / metabolism Phosphorylation Promoter Regions, Genetic RNA Interference RNA, Small Interfering / metabolism, therapeutic use Sialoglycoproteins / metabolism Transplantation, Heterologous |
| Grant Support | |
ID/Acronym/Agency:
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R01 CA119689/CA/NCI NIH HHS; R01 HD007857/HD/NICHD NIH HHS; R01 HD008188/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Hypoxia-Inducible Factor 1, alpha Subunit; 0/Macrophage Migration-Inhibitory Factors; 0/Peptide Fragments; 0/RNA, Small Interfering; 0/Sialoglycoproteins; 0/bone sialoprotein (35-62), human; EC 2.3.1.48/Nuclear Receptor Coactivator 3; EC 2.7.11.10/I-kappa B Kinase |
| Comments/Corrections | |
Comment In:
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Cell Res. 2012 Jun;22(6):950-3
[PMID:
22565285
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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