Document Detail

Steroid receptor coactivator-1: A versatile regulator and promising therapeutic target for breast cancer.
MedLine Citation:
PMID:  23474438     Owner:  NLM     Status:  Publisher    
Breast cancer is the leading cause of cancer death for women worldwide. Various therapeutic approaches have been proposed, among which endocrine therapy has recently become popular due to the high sensitivity of breast tissues to steroids such as estrogens and progesterone. The underlying mechanisms of steroid regulation in breast cancer cell proliferation, invasiveness, metastasis and endocrine resistance, however, remain largely unknown. Steroid receptor coactivator-1 (SRC-1) has attracted much attention because it is an important co-regulator and plays a pivotal role in modulating the transcriptional activities of steroid nuclear receptors. Accumulated research has established a strong correlation between SRC-1 and the pathological progression or disease-related features of breast cancer, which supports its potential as a target for specific therapeutic intervention in the clinical management of breast cancer. In addition, a diverse group of downstream molecules have also been shown to participate in various functional pathways related to SRC-1-associated regulation of breast cancer. These downstream molecules are also considered promising therapeutic targets, providing additional options for targeted treatments. In this review, the expression of SRC-1 in breast cancer and the close relationships between SRC-1 and the cell proliferation, invasiveness, metastasis and endocrine resistance of breast cancer will be discussed, followed by a brief summary of its putative functional mechanisms with an emphasis on the potential therapeutic role of SRC-1.
Yanlei Zhang; Chenyang Duan; Chen Bian; Ying Xiong; Jiqiang Zhang
Related Documents :
24023278 - Ubiquitination and the ubiquitin - proteasome system in the pathogenesis and treatment ...
24525508 - Intranodal papillary epithelial proliferations: a local process with a spectrum of morp...
23226788 - The role of aib1 in breast cancer.
23695548 - The shca ptb domain functions as a biological sensor of phospho-tyrosine signaling duri...
18620728 - Deleted in pancreatic carcinoma locus 4/smad4 participates in the regulation of apoptos...
11381198 - Sex steroid hormones in serum and tissue of benign and malignant breast tumor patients.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-3-5
Journal Detail:
Title:  The Journal of steroid biochemistry and molecular biology     Volume:  -     ISSN:  1879-1220     ISO Abbreviation:  J. Steroid Biochem. Mol. Biol.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-3-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9015483     Medline TA:  J Steroid Biochem Mol Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 Elsevier Ltd. All rights reserved.
Department of Neurobiology, Chongqing Key Laboratory of Neurobiology, Third Military Medical University, Chongqing 400038, China; Company Ten of Cadet Brigade, Third Military Medical University, Chongqing 400038, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Cytochrome P450-mediated metabolic alterations in preeclampsia evaluated by quantitative steroid sig...
Next Document:  Kinetics of Cisplatin Release by In-Vitro Using Poly(D,L-Lactide) Coated Fe3O4 Nanocarriers.