| Steroid profiling in preeclamptic women: evidence for aromatase deficiency. | |
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MedLine Citation:
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PMID: 20691412 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Experimental data have revealed the critical role played by 2-methoxy-estradiol, a metabolite of 17β-estradiol, in the pathophysiology of preeclampsia. We used gas chromatography/mass spectrometry to measure a whole panel of hormonal steroids in the plasma from women during the third trimester of their pregnancy. STUDY DESIGN: The population study consists of 24 pregnant patients with different outcomes: normal, or complicated by isolated preeclampsia or by severe preeclampsia with Hemolysis Enzyme Liver Low Platelets (HELLP) syndrome. RESULTS: 17β-estradiol was reduced by 50% in isolated preeclampsia, and by 70% in severe preeclampsia with HELLP syndrome (normal: 8.54 ± 0.9 ng/mL; isolated preeclampsia: 4.65 ± 1.0 ng/mL; severe preeclampsia with HELLP syndrome: 2.64 ± 0.4 ng/mL), as is estrone. Downstream, 2-methoxy-estradiol was decreased only in severe preeclampsia with HELLP syndrome. The concentrations of estrone and 17β-estradiol precursors were comparable between groups, suggesting that placental aromatase is deficient in preeclampsia. CONCLUSION: The gradual decrease of estrogen levels with increasing severity of preeclampsia suggests an impairment of placental steroidogenesis. |
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Authors:
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Alexandre Hertig; Philippe Liere; Nathalie Chabbert-Buffet; Julie Fort; Antoine Pianos; Bernard Eychenne; Annie Cambourg; Michael Schumacher; Nadia Berkane; Guillaume Lefevre; Serge Uzan; Eric Rondeau; Patrick Rozenberg; Marie-Edith Rafestin-Oblin |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-08-05 |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 203 ISSN: 1097-6868 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-08 Completed Date: 2010-12-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 477.e1-9 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2010 Mosby, Inc. All rights reserved. |
Affiliation:
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APHP, Urgences Néphrologiques et Transplantation Rénale and INSERM U702, Hôpital Tenon, Paris, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analysis of Variance Aromatase / blood*, deficiency Estradiol / blood* Estrone / blood Female Gas Chromatography-Mass Spectrometry HELLP Syndrome / blood* Humans Pilot Projects Pre-Eclampsia / blood* Pregnancy Pregnancy Trimester, Third / blood* |
| Chemical | |
Reg. No./Substance:
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50-28-2/Estradiol; 53-16-7/Estrone; EC 1.14.14.1/Aromatase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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