Document Detail


Steroid metabolism with intestinal microorganisms.
MedLine Citation:
PMID:  8478793     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
As a result of the metabolic activities of numerous anaerobic microorganisms with sterols, bile acids and steroid hormones as substrates in connection with the enterohepatic circulation of these compounds, the intestine may be considered as an "endocrine" active site or organ. The review summarizes transformations of steroids by anaerobic intestinal bacteria, the physiological and supposed pathophysiological meaning thereof. The aim is to recommend further investigation in this field with respect to both the elucidation of the reactions and biological responses.
Authors:
H Groh; K Schade; C Hörhold-Schubert
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of basic microbiology     Volume:  33     ISSN:  0233-111X     ISO Abbreviation:  J. Basic Microbiol.     Publication Date:  1993  
Date Detail:
Created Date:  1993-05-25     Completed Date:  1993-05-25     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8503885     Medline TA:  J Basic Microbiol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  59-72     Citation Subset:  IM    
Affiliation:
Jenaer Beutenberg-Institute, Wissenschaftler-Integrations-Programm der KAI e.V. Berlin, Jena, Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bacteria, Anaerobic / metabolism*
Bacteroides / metabolism
Biotransformation
Clostridium / metabolism
Escherichia coli / metabolism
Eubacterium / metabolism
Humans
Hydrogenation
Hydrolysis
Hydroxylation
Intestines / microbiology*
Steroids / pharmacokinetics*
Chemical
Reg. No./Substance:
0/Steroids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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